Reported to be 10- to 30-fold more potent than L-NMMA (Prod. No. ALX-106-001) as an inhibitor of inducible nitric oxide synthase (iNOS; NOS II).
Product Specification
| Alternative Name: | SMT, S-Methylisothiourea . sulfate, 2-Methyl-2-thiopseudourea . sulfate |
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| Formula: | C4H12N4S2SO4 |
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| MW: | 278.4 |
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| CAS: | 867-44-7 |
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| RTECS: | UM9200000 |
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| Purity: | ≥97% |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in HCl (25mg/ml; colorless solution). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity: G.J. Southan, et al.; Br. J. Pharmacol.
114, 510 (1995),
Abstract;
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase: C. Szabó, et al.; PNAS
91, 12472 (1994),
Abstract;
Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas: E.P. Garvey, et al.; J. Biol. Chem.
269, 26669 (1994),
Abstract;
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