| ALX-215-063-C100 | 100 µg | 315.00 USD |  |
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| Alternative Name: | LY96, Lymphocyte antigen 96, ESOP-1 |
| Host: | Rabbit |
| Immunogen: | Full length recombinant human MD-2. |
| UniProt ID: | Q9Y6Y9 |
| Species reactivity: | Human, Mouse, Rat |
| Applications: | IHC (PS), WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections, 5-10µg/ml) Western blot (0.5-2µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~30kDa by Western blot. |
| Purity Detail: | Protein G-affinity purified |
| Formulation: | Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
| Shipping: | Blue Ice |
| Short Term Storage: | +4°C |
| Long Term Storage: | -20°C |
| Scientific Background: | The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. Toll-like receptor 4 (TLR4), the principal signaling receptor for lipopolysaccharide (LPS) in mammals, requires the binding of MD-2 to its extracellular domain for maximal responsiveness. MD-2 enables TLR4 to respond to a wide variety of LPS partial structures, Gram-negative bacteria, and Gram-positive lipoteichoic acid, but not to Gram-positive bacteria, peptidoglycan, and lipopeptide. |
| Regulatory Status: | RUO - Research Use Only |
