| Alternative Name: | PI(3)K p110α/p85 |
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| MW: | p110α: ~124.3kDa; p85: ~83.5kDa. |
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| Source: | Produced in Sf9 insect cells. Bovine PI(3)K p110α/p85 dimer untagged. Produced in a baculovirus expression system. |
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| UniProt ID: | P32871 (p110α), P23727 (p85α), P23726 (p85β), O46404 (P85γ) |
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| Concentration: | 0.1mg/ml |
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| Formulation: | Liquid. Recombinant protein in 25mM HEPES, pH 8.0, 25mM sodium chloride, 2.5mM magnesium dichloride and 50% glycerol. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Specific Activity: | ~1nmol/mg/min using phosphatidyl-inositol as the substrate. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Avoid freeze/thaw cycles. |
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| Scientific Background: | Phosphoinositide 3- kinases (PI(3)Ks) phosphorylate the 3'-OH position of inositol phospholipids. The heterodimeric complex consists of a catalytic subunit (p110α) and a regulatory adaptor subunit (p85). The PI(3)K regulates the MAP kinase and the Akt/PKB signalling pathway that is involved in pivotal cellular processes such as mitogenesis, apoptosis and cytoskeletal functions, and also plays an important role in the development of human cancer. |
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| Regulatory Status: | RUO - Research Use Only |
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