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Phosphoinositide 3-kinase p110α/p85 (bovine), (recombinant)

ALX-201-119-C005 5 µg 318.00 USD
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Product Specification

Alternative Name:PI(3)K p110α/p85
MW:p110α: ~124.3kDa; p85: ~83.5kDa.
Source:Produced in Sf9 insect cells. Bovine PI(3)K p110α/p85 dimer untagged. Produced in a baculovirus expression system.
UniProt ID:P32871 (p110α), P23727 (p85α), P23726 (p85β), O46404 (P85γ)
Formulation:Liquid. Recombinant protein in 25mM HEPES, pH 8.0, 25mM sodium chloride, 2.5mM magnesium dichloride and 50% glycerol.
Purity:≥90% (SDS-PAGE)
Specific Activity:~1nmol/mg/min using phosphatidyl-inositol as the substrate.
Shipping:Shipped on Dry Ice
Long Term Storage:-20°C
Handling:Avoid freeze/thaw cycles.
Scientific Background:Phosphoinositide 3- kinases (PI(3)Ks) phosphorylate the 3'-OH position of inositol phospholipids. The heterodimeric complex consists of a catalytic subunit (p110α) and a regulatory adaptor subunit (p85). The PI(3)K regulates the MAP kinase and the Akt/PKB signalling pathway that is involved in pivotal cellular processes such as mitogenesis, apoptosis and cytoskeletal functions, and also plays an important role in the development of human cancer.
Regulatory Status:RUO - Research Use Only

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