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HSC70/HSP73 polyclonal antibody

ADI-SPA-819-D 50 µg 194.00 USD
ADI-SPA-819-F 200 µg 457.00 USD
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Product Details

Alternative Name:Heat shock protein 70, Hsc70, Hsp73
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human HSC70 (HSP73). The sequence is completely conserved in rat, mouse, bovine, dog, chicken, monkey, and frog.
UniProt ID:P11142
Source:Purified from rabbit serum.
Species reactivity:Human, Mouse, Rat
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~73kDa by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1's role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate binding domain of Hsd70 cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.
Regulatory Status:RUO - Research Use Only
HSC70/HSP73 polyclonal antibody Western blot
Western blot analysis of HSC70 (HSP73) pAb: Lane 1: HeLa Cell Lysate, Lane 2: HeLa Cell Lysate (Heat Shocked), Lane 3: PC -12 Cell Lysate, Lane 4: PC -12 Cell Lysate (Heat Shocked), Lane 5: 3T3 Cell Lysate, Lane 6: 3T3 Cell Lysate (Heat Shocked), Lane 7: HSC70 (HSP73) Recombinant Protein (Prod. No. ADI-SPP-751).
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HSC70/HSP73 polyclonal antibody Western blot

Product Literature References

Early triggers of moderately high-fat diet-induced kidney damage: A. Sánchez Navarro, et al.; Physiol. Rep. 9, 14937 (2021), Abstract;

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