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[pSer19]αB-Crystallin polyclonal antibody

ADI-SPA-225-C 25 µg 188.00 USD
ADI-SPA-225-E 100 µg 387.00 USD
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Product Details

Alternative Name:CRYAB, HSPB5
Immunogen:Synthetic peptide corresponding to a portion of human αB-crystallin. The sequence is completely conserved in mouse, rat and bovine phosphorylated at Ser19.
UniProt ID:P02511
Source:Purified from rabbit serum.
Species reactivity:Human, Mouse
Applications:IP, WB
Recommended Dilutions/Conditions:Immunoprecipitation (12.5µg/ml)
Western Blot (1µg/ml, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Formulation:Liquid. In sodium phosphate buffer, pH 7.0, containing 3% BSA.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Alpha-crystallins, which are part of the small Heat shock family members, are major water-soluble proteins present in the lens of the mammalian eye. Phosphorylation of serine residues which occurs during development and in response to stress, is intimately linked with its function. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation.
Regulatory Status:RUO - Research Use Only
[pSer19]αB-Crystallin polyclonal antibody Western blot
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[pSer19]αB-Crystallin polyclonal antibody Western blot

Product Literature References

Phosphorylation of the chaperone-like HspB5 rescues trafficking and function of F508del-CFTR: F. Degrugillier, et al.; Int. J. Mol. Sci. 21, E4844 (2020), Application(s): Western-blot using CFBE cells, Abstract;
AlphaB-crystallin expression correlates with aging deficits in the peripheral nervous system: E.M.F. Lim, et al.; Neurobiol. Aging 53, 318 (2017), Application(s): Western-blot using mouse sciatic nerve lysates, Abstract;
Phosphorylation and degradation of αB-crystallin during enterovirus infection facilitates viral replication and induces viral pathogenesis: G. Fung, et al.; Oncotarget 8, 74767 (2017), Application(s): Western-blot using HL-1 cells and mouse cardiac tissue, Abstract; Full Text
Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/αB-crystallin after transient middle cerebral artery occlusion in rats: B. Bartelt-Kirbach, et al.; Cell Stress Chaperones 22, 653 (2017), Abstract; Full Text
Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis: S.W. Lee, et al.; PLoS One 11, e0166450 (2016), Abstract; Full Text
HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line: A.N. Graner, et al.; Int. J. Hyperthermia 20, 1 (2016), Abstract; Full Text

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