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Notch1 monoclonal antibody (3E12)

ADI-905-897-100 100 µl 447.00 USD
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Product Details

Immunogen:Recombinant human Notch1 (aa 2300-2556).
UniProt ID:P46531
Species reactivity:Human
Recommended Dilutions/Conditions:Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~280kDa (full length) by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Notch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
Regulatory Status:RUO - Research Use Only
Notch1 monoclonal antibody (3E12) Western blot
Western blot analysis of HEK293T cells transfected with the pCMV6-ENTRY control (lane 1) or pCMV6-ENTRY Notch1 cDNA,(lane 2) probed with Notch1 mAb (3E12).
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Notch1 monoclonal antibody (3E12) Western blot

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