The PATHO-GENE® HPV type 31/33/51 probe is a mixture of biotin-labeled HPV 31, HPV 33 and HPV 51-specific probes in buffered formamide and hybridization enhancers.
Product Details
Application Notes: | The ENZO PATHO-GENE® HPV type 31/33/51 probe employs a mixture of the HPV 31, HPV 33 and HPV 51-specific probes that detect HPV types that have been associated with either condyloma or cervical intraepithelial neoplasia (CIN) and carcinoma in situ (CIS). The probe mixture is denatured and hybridized to the tissue section fixed and pretreated on the microscope slide. Specific hybridization between the HPV DNA probe and DNA in the specimen is determined by the detection of biotin. |
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Shipping: | Blue Ice |
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Long Term Storage: | +4°C |
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Use/Stability: | Stable for at least one year after receipt when stored as recommended. |
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Technical Info/Product Notes: | HPV probe can be optimized for polymer detection system using diluent buffer, In situ hybridization buffer for HPV probes (Ready-to Use) (Prod. No. ENZ-33905).
This product or the use of this product is covered by one or more Enzo patents, including, but not limited to the following: U.S. Patent No. 4,994,373; Canadian Patent No. 1,309,672; and patents pending. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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HPV DNA detection by in situ hybridization with catalyzed signal amplification on thin-layer cervical smears: B. Samama, et al.; J. Histochem. Cytochem.
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Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia: M.C. Bleeker, et al.; J. Am. Acad. Dermatol.
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Human papillomaviruses 6/11, 16/18 and 31/33/51 are not associated with squamous cell carcinoma of the urinary bladder: P.J. Westenend, et al.; BJU Int.
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Full Text
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Sensitivity of in situ detection with biotinylated probes of human papilloma virus type 16 DNA in frozen tissue sections of squamous cell carcinomas of the cervix: J.M. Walboomers, et al.; Am. J. Pathol.
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Detection of viral genomes in cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes: D.J. Brigati, et al.; Virology
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Enzymatic synthesis of biotin-labeled polynucleotides: novel nucleic acid affinity probes: P.R. Langer, et al.; PNAS
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