The PATHO-GENE® HPV type 6/11 probe is a mixture of biotin-labeled HPV 6 and HPV 11-specific probes in buffered formamide and hybridization enhancers.
Product Details
| Application Notes: | The ENZO PATHO-GENE® HPV type 6/11 probe employs a mixture of the HPV 6 and HPV 11-specific probes that detect HPV types that have been associated with benign lesions presenting as condylomas and mild dysplasia. The probe mixture is denatured and hybridized to the tissue section fixed and pretreated on the microscope slide. Specific hybridization between the HPV DNA probe and DNA in the specimen is determined by the detection of biotin. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable for at least one year after receipt when stored as recommended. |
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| Technical Info/Product Notes: | HPV probe can be optimized for polymer detection system using diluent buffer, In situ hybridization buffer for HPV probes (Ready-to Use) (Prod. No. ENZ-33905).
This product or the use of this product is covered by one or more Enzo patents, including, but not limited to the following: U.S. Patent No. 4,994,373; Canadian Patent No. 1,309,672; and patents pending. |
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| Regulatory Status: | RUO - Research Use Only |
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Negative detection of HPV 6/11 with ENZ-32885 PATHO-GENE® HPV 6/11 probes in cervical FFPE tissue.
Positive detection of HPV 6/11 (red) with ENZ-32885 PATHO-GENE® HPV 6/11 probes in vulva FFPE tissue.
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Product Literature References
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A cardiac allograft recipient with Bowen's disease on a finger and concurrent perianal bowenoid papulosis: M. Ibe, et al.; J. Dermatol.
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MIB-1 immunostaining is a beneficial adjunct test for accurate diagnosis of vulvar condyloma acuminatum: E.C. Pirog, et al.; Am. J. Surg. Pathol.
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Chromosome fragility in lymphocytes of women with cervical uterine lesions produced by human papillomavirus: C. Paz-y-Miño, et al.; Cancer Genet. Cytogenet.
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Comparison of four in situ hybridization methods, based on digoxigenin- and biotin-labelled probes, in detecting HPV DNA in male condylomata acuminata: J. Lassus, et al.; Int. J. STD AIDS
3, 196 (1992),
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Correlation of the expression of Epstein-Barr virus latent membrane protein and in situ hybridization with biotinylated BamHI-W probes in Hodgkin's disease: G. Delsol, et al.; Am. J. Pathol.
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Demonstration of human papillomavirus DNA in a peripheral ameloblastoma by in situ hybridization: M.A. Kahn, et al.; Hum. Pathol.
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Human papillomavirus infection and anal carcinoma. Retrospective analysis by in situ hybridization and the polymerase chain reaction: S.R. Zaki, et al.; Am. J. Pathol.
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Superficial nuclear enlargement without koilocytosis as an expression of human papillomavirus infection of the uterine cervix: an in situ hybridization study: G.C. Yang, et al.; Int. J. Gynecol. Pathol.
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Full Text
A rapid DNA probe test for detecting human papilloma virus types 6/11 and 16 in biopsy specimens: J.A. Todd, et al.; Mol. Cell. Probes
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Application(s): in situ hybridization,
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Sensitivity of in situ detection with biotinylated probes of human papilloma virus type 16 DNA in frozen tissue sections of squamous cell carcinomas of the cervix: J.M. Walboomers, et al.; Am. J. Pathol.
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