Replaces Prod. #: ALX-480-047
A cAMP analog which is a potent and specific activator of cAMP-dependent protein kinase. It is cell permeable and is not significantly hydrolyzed by type I, II or III phosphodiesterases. It may be used to distinguish the cAMP- versus the cGMP-mediated signal transduction pathways. Surpasses the widely used but problematic dibutyryl-cAMP (Prod. No. BML-CN125) or 8-CPT-cAMP (Prod. No. BML-CN130).
Product Details
| Formula: | C12H10N2O5PSCl2 . Na |
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| MW: | 419.2 |
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| Source: | Synthetic. |
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| CAS: | 120912-54-1 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (167 mM), dimethyl formamide (167 mM), 96 % ethanol (167 mM), methanol (25 mM), water (25 mM) and aqueous buffers such as phostphate buffered saline (pH 7.4; 1.4 mM), 25 mM TRIS (pH 7.4-; 25 mM), 25 mM HEPES (pH 7.2; 35.7 mM) or Na2HPO4. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Comparative characteristics between calyculin A-induced and thimerosal-induced hyperactivation of cryopreserved bovine spermatozoa: N. Miyamoto, et al.; J. Reprod. Dev.
69, 170 (2023),
Abstract;
Changes of IZUMO1 in bull spermatozoa during the maturation, acrosome reaction and cryopreservation: M. Fukuda, et al.; Theriogenology
86, 2179 (2016),
Application(s): Treatments for induction of the acrosome reaction,
Abstract;
Involvement of cyclic AMP-dependent unique signaling cascades in the decrease of serine/threonine-phosphorylated proteins in boar sperm head: A. Isono, et al. ; Theriogenology
85, 1152 (2016),
Application(s): Incubation of spermatozoa for induction of acrosome reaction,
Abstract;
Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium: P. Schaap et al.; J. Biol. Chem.
268, 6323 (1993),
Abstract;
Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg et al.; Biochem. J.
279 ( Pt 2), 521 (1991),
Abstract;
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