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PKA activator
BML-CN130-0020 20 mg 85.00 USD
BML-CN130-0100 100 mg 348.00 USD
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Replaces Prod. #: ALX-480-030

A lipophilic, cell-permeable cAMP analog which activates cAMP- and cGMP-dependent protein kinase.  More potent than cAMP and more resistant to phosphodiesterasese, with good selectivity for site B of PKA. For specific activation of the cAMP pathway the highly membrane permeable Sp-5,6-DCI-cBIMPS (Prod. No. BML-CN135).

Product Details

Formula:C16H14CIN5O6PS . Na
Purity:≥96% (HPLC)
Appearance:White solid.
Solubility:Soluble in water (25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Store as supplied (solid) at -20°C for 1 year. Once dissolved in water, it can be stored frozen at -20°C up to 3 months.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell: X. Liu, et al.; Cell Death Dis. 14, 142 (2023), Abstract;
Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase: B. Zhou, et al.; Cell Rep. 37, 109785 (2021), Abstract;
The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis: M. Ploton, et al.; J. Hepatol. 69, 1099 (2018), Abstract;
Glucagon-like peptide-1 Regulates Cholecystokinin Production in β-cells to Protect from Apoptosis: A.K. Linnemann, et al.; Mol. Endocrinol. 29, 978 (2015), Application(s): Cell Culture, Abstract; Full Text
Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells: Y. Cay, et al.; Arterioscler. Thromb. Vasc. Biol. 31, 616 (2011), Abstract; Full Text
The role of protein kinase A anchoring via the RII alpha regulatory subunit in the murine immune system: R.V. Schillace et al.; J. Immunol. 174, 6847 (2005), Abstract;
8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA): B.J. Connolly et al.; Biochem. Pharmacol. 44, 2303 (1992), Abstract;
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets: J. Geiger et al.; PNAS 89, 1031 (1992), Abstract;
Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg et al; Biochem. J. 279 , 521 (1991), Abstract;
Stoichiometric and reversible phosphorylation of a 46-kDa protein in human platelets in response to cGMP- and cAMP-elevating vasodilators: M. Halbrugge et al.; J. Biol. Chem. 265, 3088 (1990), Abstract;
Comparison of the two classes of binding sites (A and B) of type I and type II cyclic-AMP-dependent protein kinases by using cyclic nucleotide analogs: D. Ogreid et al.; Eur. J. Biochem. 181, 19 (1989), Abstract;
cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor: R.E. Rydel & L.A. Greene; PNAS 85, 1257 (1988), Abstract;

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