Replaces Prod. #: ALX-480-030
A lipophilic, cell-permeable cAMP analog which activates cAMP- and cGMP-dependent protein kinase. More potent than cAMP and more resistant to phosphodiesterasese, with good selectivity for site B of PKA. For specific activation of the cAMP pathway the highly membrane permeable Sp-5,6-DCI-cBIMPS (Prod. No. BML-CN135).
Product Details
| Formula: | C16H14CIN5O6PS . Na |
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| MW: | 493.8 |
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| Source: | Synthetic. |
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| CAS: | 93882-12-3 |
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| Purity: | ≥96% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store as supplied (solid) at -20°C for 1 year. Once dissolved in water, it can be stored frozen at -20°C up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell: X. Liu, et al.; Cell Death Dis.
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Abstract;
Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase: B. Zhou, et al.; Cell Rep.
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Abstract;
The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis: M. Ploton, et al.; J. Hepatol.
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Glucagon-like peptide-1 Regulates Cholecystokinin Production in β-cells to Protect from Apoptosis: A.K. Linnemann, et al.; Mol. Endocrinol.
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Application(s): Cell Culture,
Abstract;
Full Text
Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells: Y. Cay, et al.; Arterioscler. Thromb. Vasc. Biol.
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Abstract;
Full Text
The role of protein kinase A anchoring via the RII alpha regulatory subunit in the murine immune system: R.V. Schillace et al.; J. Immunol.
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Abstract;
8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA): B.J. Connolly et al.; Biochem. Pharmacol.
44, 2303 (1992),
Abstract;
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets: J. Geiger et al.; PNAS
89, 1031 (1992),
Abstract;
Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg et al; Biochem. J.
279 , 521 (1991),
Abstract;
Stoichiometric and reversible phosphorylation of a 46-kDa protein in human platelets in response to cGMP- and cAMP-elevating vasodilators: M. Halbrugge et al.; J. Biol. Chem.
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Abstract;
Comparison of the two classes of binding sites (A and B) of type I and type II cyclic-AMP-dependent protein kinases by using cyclic nucleotide analogs: D. Ogreid et al.; Eur. J. Biochem.
181, 19 (1989),
Abstract;
cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor: R.E. Rydel & L.A. Greene; PNAS
85, 1257 (1988),
Abstract;
