Replaces Prod. #: BML-CN262
Carboxy-PTIO is a water-soluble and stable nitric oxide radical scavenger that shows in chemical and biological systems antagonistic action against the free nitric oxide radical (NO·) in a stoichiometric manner. The inhibitory effects are almost two-fold stronger than those of NMMA (Prod. No. ALX-106-001) and NOARG (Prod. No. ALX-105-001). Carboxy-PTIO can be used for an improved detection of nitric oxide in activated macrophage cultures in combination with the Griess reagent (Prod. No. ALX-400-004). Carboxy-PTIO also protects against endotoxin shock.
Product Details
| Alternative Name: | 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide . potassium salt |
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| Formula: | C14H16N2O4 . K |
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| MW: | 315.4 |
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| CAS: | 148819-94-7 |
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| Purity: | ≥99% (HPLC) |
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| Identity: | Identity determined by MS and NMR. |
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| Appearance: | Blue solid. |
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| Solubility: | Soluble in DMF, DMSO, 100% ethanol, or 100% methanol. Highly soluble in water or aqueous buffers (e.g. PBS, pH 7.2). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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General Literature References
Reaction between imidazolineoxil N-oxide (carboxy-PTIO) and nitric oxide released from cultured endothelial cells: quantitative measurement of nitric oxide by ESR spectrometry: T. Az-ma, et al.; Life Sci.
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