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L-NMMA . monoacetate

NOS inhibitor
ALX-106-001-M025 25 mg 77.00 USD
ALX-106-001-M100 100 mg 270.00 USD
ALX-106-001-G001 1 g 433.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: BML-EI182

Competitively inhibits the generation of NO from arginine and is a useful tool for inhibition of NO mediated effects. In vitro, L-NMMA inhibits relaxation of rat aorta rings induced by acetylcholine (IC50=9.5µM). In vivo, it causes a dose dependent increase in mean arterial blood pressure in anesthetized rats (EC50=16.7mg/kg).

Product Details

Alternative Name:NG-Monomethyl-L-arginine . monoacetate
Formula:C7H16N4O2 . CH3COOH
MW:188.2 . 60.1
Purity:≥99% (TLC)
Appearance:White to off-white solid.
Solubility:Soluble in water, 100% ethanol (1mg/ml) or DMSO (0.25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Seco- and isopimarane diterpenoids from Kaempferia marginata rhizomes and their NO inhibition activities: K.M. Do, et al.; Phytochemistry 205, 113510 (2023), Abstract;
Cytokine and Nitric Oxide-Dependent Gene Regulation in Islet Endocrine and Nonendocrine Cells: J.S. Stancill, et al.; Function (Oxf.) 3, zqab063 (2022), Abstract;
Marginols A‒H, unprecedented pimarane diterpenoids from Kaempferia marginata and their NO inhibitory activities: K.M. Do, et al.; Phytochemistry 196, 113109 (2022), Abstract;
Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB0,+) Selectively Reduces Access for Cationic Amino Acids and Derivatives: C.M.H. Anderson, et al.; Biomolecules 12, 1404 (2022), Abstract;
Regulation of ATR-dependent DNA damage response by nitric oxide: C.T. Yeo, et al.; J. Biol. Chem. 296, 100388 (2021), Abstract;
Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis: S. Pfister, et al.; J. Thorac. Cardiovasc. Surg. 141, 425 (2011), Abstract; Full Text
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase: M. Palacios-Callender, et al.; PNAS 101, 7630 (2004), Abstract; Full Text
Nitric oxide: an endogenous modulator of leukocyte adhesion: P. Kubes, et al.; PNAS 88, 4651 (1991), Abstract;
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo: D.D. Rees, et al.; Br. J. Pharmacol. 101, 746 (1990), Abstract;
A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation: D.D. Rees, et al.; Br. J. Pharmacol. 96, 418 (1989), Abstract;
NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo?: K. Aisaka, et al.; BBRC 160, 881 (1989), Abstract;
Identification of arginine as a precursor of endothelium-derived relaxing factor: I. Sakuma, et al.; PNAS 85, 8664 (1988), Abstract;

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