Replaces Prod. #: BML-EI182
Competitively inhibits the generation of NO from arginine and is a useful tool for inhibition of NO mediated effects. In vitro, L-NMMA inhibits relaxation of rat aorta rings induced by acetylcholine (IC50=9.5µM). In vivo, it causes a dose dependent increase in mean arterial blood pressure in anesthetized rats (EC50=16.7mg/kg).
Product Details
| Alternative Name: | NG-Monomethyl-L-arginine . monoacetate |
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| Formula: | C7H16N4O2 . CH3COOH |
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| MW: | 188.2 . 60.1 |
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| CAS: | 53308-83-1 |
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| Purity: | ≥99% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water, 100% ethanol (1mg/ml) or DMSO (0.25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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205, 113510 (2023),
Abstract;
Cytokine and Nitric Oxide-Dependent Gene Regulation in Islet Endocrine and Nonendocrine Cells: J.S. Stancill, et al.; Function (Oxf.)
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Abstract;
Marginols A‒H, unprecedented pimarane diterpenoids from Kaempferia marginata and their NO inhibitory activities: K.M. Do, et al.; Phytochemistry
196, 113109 (2022),
Abstract;
Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB0,+) Selectively Reduces Access for Cationic Amino Acids and Derivatives: C.M.H. Anderson, et al.; Biomolecules
12, 1404 (2022),
Abstract;
Regulation of ATR-dependent DNA damage response by nitric oxide: C.T. Yeo, et al.; J. Biol. Chem.
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Abstract;
Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis: S. Pfister, et al.; J. Thorac. Cardiovasc. Surg.
141, 425 (2011),
Abstract;
Full Text
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase: M. Palacios-Callender, et al.; PNAS
101, 7630 (2004),
Abstract;
Full Text
Nitric oxide: an endogenous modulator of leukocyte adhesion: P. Kubes, et al.; PNAS
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Abstract;
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo: D.D. Rees, et al.; Br. J. Pharmacol.
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Abstract;
A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation: D.D. Rees, et al.; Br. J. Pharmacol.
96, 418 (1989),
Abstract;
NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo?: K. Aisaka, et al.; BBRC
160, 881 (1989),
Abstract;
Identification of arginine as a precursor of endothelium-derived relaxing factor: I. Sakuma, et al.; PNAS
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Abstract;
