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BIOLIKE® Bevacizumab conformational ELISA kit

Systematic and sensitive immunoassay to compare the structural conformation between Bevacizumab and a biosimilar mAb.
 
ENZ-KIT118-0003 3x96 wells 964.00 USD
Do you need bulk/larger quantities?
 
  • Unique measurement of biosimilar mAb Higher Order Structure (HOS) comparability
  • High throughput format with results in 3 hours
  • Correlates well with bioassays and glycosylation analysis
The BIOLIKE® Bevacizumab conformational ELISA kit is a systematic and sensitive immunoassay that uses a panel of more than 30 antibodies to measure the structural conformation of Bevacizumab to enable a Higher Order Structure (HOS) comparison to a biosimilar mAb.
ENZ-KIT118 Fig1
A typical ELISA , with only the Bevacizumab reference protein, in the variable region
ENZ-KIT118 Fig2
A typical ELISA , with only the Bevacizumab reference protein, in the constant region
Please mouse over
ENZ-KIT118 Fig1 ENZ-KIT118 Fig2

Product Specification

Assay Time:3 hours
 
Applications:ELISA, Colorimetric detection
 
Application Notes:For the systematic 3-D conformational comparability analysis of a biosimilar to Bevacizumab.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Kit/Set Contains:3 x 96 well plates, 5x dilution buffer, 10x PBS-T, reporting antibody, streptavidin-HRP conjugate, TMB substrate, stop solution, plate sealer
 
Scientific Background:Bevacizumab is a humanized monoclonal antibody that inhibits vascular endothelial growth factor A (VEGF-A). VEGF-A is a chemical signal that stimulates angiogenesis in a variety of diseases, especially in cancer. Bevacizumab was the first clinically available angiogenesis inhibitor in the United States and was approved by the U.S. Food and Drug Administration (FDA) for certain metastatic cancers. It received its first approval in 2004 for combination use with standard chemotherapy for metastatic colon cancer. This kit will allow for conformational comparison between biosimilars and authentic Bevacizumab.
 
Technical Info/Product Notes:Biologic comparability is essential to the successful development process of biosimilars; the 3-D conformation of a protein is an important factor in its biological function. Due to their large size and rotational characteristic, proteins generally exhibit complex 3-D conformations.

Enzo Life Sciences' line of BIOLIKE® conformational ELISA kits provide a sensitive, systematic, and robust measurement of biosimilar conformation comparability at the molecular level. The BIOLIKE® conformational ELISA kit allows for HOS characterization between biosimilars and marketed mAbs.
 

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