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Niltubacin

HDAC inhibitor
 
BML-GR363-0100 100 µg 75.00 USD
 
BML-GR363-0500 500 µg 303.00 USD
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Negative control for Tubacin (tubulin acetylation inducer), a highly potent and selective, reversible, cell-permeable inhibitor of HDAC6. Concentration of niltubacin in cell culture experiments typically ranges from 2-20µM.

Product Specification

Alternative Name:7-(4-((2R,4R,6S)-4-((4,5-dipenyloxazol-2-ylthio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenylcarbamoyl)heptanoic acid
 
Formula:C41H42N2O7S
 
MW:706.9
 
Source:Synthetic.
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (6 mg/ml).
 
Shipping:Shipped on Dry Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-80°C
 
Use/Stability:Stable for at least one year after receipt when stored at -80°C.
 
BML-GR363 structure
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BML-GR363 structure

Product Literature References

Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents: M. Namdar, et al.; Proc. Natl. Acad. Sci. USA 107, 20003 (2010), Abstract; Full Text
Histone deacetylase 6 interacts with the microtubule-associated protein tau: H. Ding, et al.; J. Neurochem. 106, 2119 (2008), Abstract; Full Text
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation: S.J. Haggarty, et al.; Proc. Natl. Acad. Sci. USA 100, 4389 (2003), Abstract; Full Text

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