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Tubacin

HDAC inhibitor
 
BML-GR362-0100 100 µg 117.00 USD
 
BML-GR362-0500 500 µg 479.00 USD
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Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable inhibitor of HDAC6 (IC50=0.004µM). IC50's for the other HDACs are 1000-fold higher, making tubacin both more selective and more potent than Tubastatin A, which also inhibits HDAC8. Concentration in cell culture experiments typically ranges from 2-50µM.

Product Details

Alternative Name:N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-1,3-oxazol-2-yl)sulfanyl]methyl}-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl}phenyl)-N'-hydroxyoctanediamide
 
Formula:C41H43N3O7S
 
MW:721.9
 
Source:Synthetic.
 
CAS:537049-40-4
 
Purity:≥96% (ELSD)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (10 mg/ml).
 
Shipping:Shipped on Dry Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-80°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -80°C.
 
Regulatory Status:RUO - Research Use Only
 
BML-GR362 Structure
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BML-GR362 Structure

Product Literature References

Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation: Y. Nomura, et al.; Front. Physiol. 12, 675724 (2021), Abstract;
LC3A Silencing Hinders Aggresome Vimentin Cage Clearance in Primary Choroid Plexus Carcinoma: M. Nassar, et al.; Sci. Rep. 7, 8022 (2017), Application(s): Measurement of cell index against different concentration, Abstract; Full Text
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, Tubastatin A: K.V. Butler, et al.; J. Am. Chem. Soc. 370, 10842 (2010), Abstract;
Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents: M. Namdar, et al.; Proc. Natl. Acad. Sci. USA 107, 20003 (2010), Abstract; Full Text
Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis: J. Kawada, et al.; J. Biol. Chem. 284, 17102 (2009), Abstract; Full Text
Histone deacetylase 6 interacts with the microtubule-associated protein tau: H. Ding, et al.; J. Neurochem. 106, 2119 (2008), Abstract; Full Text
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation: S.J. Haggarty, et al.; Proc. Natl. Acad. Sci. USA 100, 4389 (2003), Abstract; Full Text
Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays: S.J. Haggarty, et al.; Chem. Biol. 10, 383 (2003), Abstract;
Structural biasing elements for in-cell histone deacetylase paralog selectivity: J.C. Wong, et al.; J. Am. Chem. Soc. 125, 5586 (2003), Abstract;
Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin: S.M. Sternson, et al.; Org. Lett. 3, 4239 (2001), Abstract;

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