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1,4-DPCA

HIF-1α activator
 
BML-EI377-0050 50 mg 152.00 USD
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1,4 DPCA blocks the proteasomal degradation of HIF-1α, inducing constitutive HIF-1α activation.

Product Specification

Formula:C13H8N2O3
 
MW:240.2
 
CAS:331830-20-7
 
Purity:≥98% (HPLC)
 
Appearance:Tan solid.
 
Solubility:Soluble in DMSO (2.5 mg/ml, warm); ethanol (5 mg/ml, warm); DMF (5 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
BML-EI377 structure
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BML-EI377 structure

Product Literature References

Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones: T.J. Franklin, et al.; Biochem. J. 353, 333 (2001), Abstract;

General Literature References

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFkB activation in the tumor stromal microenvironment.: Martinez-Outschoorn, et. al.; Cell Cycle 9(17), 3515 (2010), Abstract;

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