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Cytochrome P450 2D6 (human) polyclonal antibody

 
BML-CR3245-0025 25 µl 100.00 USD
 
BML-CR3245-0100 100 µl 320.00 USD
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Product Specification

Alternative Name:CYP2D6
 
Host:Sheep
 
Immunogen:Synthetic peptide corresponding to the C-terminus of human CYP2D6.
 
UniProt ID:P10635
 
Species reactivity:Human
 
Specificity:Recognizes human CYP2D6.
 
Applications:IHC, WB
 
Blocking Peptide:For Blocking peptide see Prod. No. BML-CP0265.
 
Formulation:Liquid. Serum containing 0.01% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Human cytochrome P-450 2D6 (CYP2D6) is responsible for the metabolism of many psychotherapeutic drugs, and has been shown to act on MPTP a thermal product of synthetic heroin, which causes Parkinson's Disease (PD)-like symptoms in man. Mutation in the cyp2D6 gene has been reported to be associtated with PD. The association between Parkinson's Disease and genetic polymorphism in the human CYP2D6 gene has been reported. CYP2D6 has been found in first trimester human fetal liver, and in the placenta. Rat CYP2D1, the homolgue of human CYP2D6, has been shown to catalyse the conversion of hydrocodone to hydromorphone, and in rat liver microsomes it participates in the conversion of ethylmorphine to codeine and morphine.
 

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