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Matrix Metalloproteinase-9 (MMP-9) fluorometric drug discovery kit

 
BML-AK411-0001 96 wells 496.00 USD
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A QuantiZyme™ Assay System. The MMP-9 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-9 (MMP-9, gelatinase B) using a quenched fluorogenic peptide: OMNIMMP® fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties. The assays are performed in a convenient 96-well microplate format. The kit is useful to screen inhibitors of MMP-9, a potential therapeutic target. Included are active enzyme, assay buffer, a prototypic control inhibitor (NNGH)3, and a detailed instruction booklet.

Product Specification

Alternative Name:Gelatinase B, 92kDa Type IV collagenase
 
Applications:Fluorescent detection, HTS
Activity assay
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Kit/Set Contains:MMP-9 enzyme (human) (recombinant), substrate, calibration standard, inhibitor, assay buffer, 96-well white microplate.
 
UniProt ID:P14780
 

Product Literature References

Targeting androgen receptor/Src complex impairs the aggressive phenotype of human fibrosarcoma cells: G. Castoria, et al.; PLoS One 8, e76899 (2013), Abstract; Full Text
Interplay between steroid receptors and neoplastic progression in sarcoma tumors: A. Fiorelli, et al.; J. Cell. Physiol. 226, 2997 (2011), Abstract;
Negative regulation of stress-induced matrix metalloproteinase-9 by Sirt1 in skin tissue: J.S. Lee, et al.; Exp. Dermatol. 19, 1060 (2010), Abstract;

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MMP-9 (catalytic domain) (human), (recombinant, E. coli) 

Produced in E. coli. Active recombinant matrix metalloproteinase-9 (MMP-9, gelatinase B, 92 kDa type IV collagenase) cloned from human cDNA. The enzyme consists of residues Phe107-Pro449 (NM_004994), which comprises the catalytic/fibronectin domain of human MMP-9, with a C-terminal purification tag. This represents a naturally-occurring active form of MMP-9 which lacks the C-terminal hemopexin domain. Activity toward its targets, such as gelatin, casein, or peptide substrates, is unaffected., ≥95% (SDS-PAGE) | Print as PDF
 
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MMP
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MMP-9 Activity kit
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