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Matrix Metalloproteinase-9 (MMP-9) colorimetric drug discovery kit

BML-AK410-0001 96 wells 536.00 USD
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A QUANTIZYME® Assay System. The MMP-9 Colorimetric Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-9 (MMP-9, gelatinase B) using a thiopeptide as a chromogenic substrate. The assays are performed in a convenient 96-well microplate format. The kit is useful to screen inhibitors of MMP-9, a potential therapeutic target. Included are active enzyme, assay buffer, a prototypic control inhibitor (NNGH), and a detailed instruction booklet.

Product Specification

Alternative Name:Gelatinase B, 92kDa Type IV collagenase
Applications:Colorimetric detection, HTS
Activity assay
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Contents:MMP-9 enzyme (human) (recombinant), substrate, inhibitor, assay buffer, 96-well microplate.
UniProt ID:P14780

Product Literature References

Toxicological effects of NCKU-21, a phenanthrene derivative, on cell growth and migration of A549 and CL1-5 human lung adenocarcinoma cells: H.F. Liao, et al.; PLoS One 12, e28945763 (2017), Abstract; Full Text
Novel in vitro inhibitory functions of potato tuber proteinaceous inhibitors: M. Fischer, et al.; Mol. Genet. Genomics 290, 387 (2015), Abstract; Full Text
Membrane localization of membrane type 1 matrix metalloproteinase by CD44 regulates the activation of pro-matrix metalloproteinase 9 in osteoclasts: M.A. Chellaiah, et al.; Biomed. Res. Int. 2013, Article ID 302392 (2013), Abstract; Full Text
Silver nanoparticles in therapeutics: development of an antimicrobial gel formulation for topical use: J. Jain, et al.; Mol. Pharm. 6, 1388 (2009), Abstract;
Actin polymerization modulates CD44 surface expression, MMP‐9 activation, and osteoclast function: V. Samanna, et al.; J. Cell. Physiol. 213, 710 (2007), Abstract;
Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression, MMP-2 secretion, and cell migration by osteopontin in human melanoma cells: V. Samanna, et al.; Exp. Cell. Res. 312, 2214 (2006), Abstract;

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