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Thyroid Peroxidase (human) monoclonal antibody (TPO 47)

 
ALX-BC-6010-S-L001 1 ml 389.00 USD
 
ALX-BC-6010-S-L005 5 ml 1,404.00 USD
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Product Specification

Alternative Name:TPO
 
Clone:TPO 47
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Human TPO (thyroid peroxidase).
 
UniProt ID:P07202
 
Species reactivity:Human
 
Specificity:Recognizes a linear epitope (aa 713-721) on human TPO protein.
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections)
Western Blot (dilution 1:2-1:10).
 
Application Notes:Assists immunocytological diagnosis of malignancy on fine needle aspirates (FNA) of thyroid nodules. Strongly stains human TPO in normal thyroid tissues but does not recognize tumoral human TPO.
 
Formulation:Sterile supernatant. 0.6 - 0.9g/ml. Contains 0.1% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 

Product Literature References

Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity: D.O. McDonald & S.H. Pearce; J. Mol. Med. 87, 971 (2009), Abstract; Full Text
BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer: C. Romei, et al.; Endocr. Relat. Cancer 2, 511 (2008), Abstract;
Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma: M. Landriscina, et al.; J. Clin. Endocrinol. Metab. 90, 5663 (2005), Abstract; Full Text
Type I interferons modulate the expression of thyroid peroxidase, sodium/iodide symporter, and thyroglobulin genes in primary human thyrocyte cultures: N. Caraccio, et al.; J. Clin. Endocrinol. Metab. 90, 1156 (2005), Abstract; Full Text
Molecular model, calcium sensitivity, and disease specificity of a conformational thyroperoxidase B-cell epitope: V. Estienne, et al.; J. Biol. Chem. 274, 35313 (1999), Abstract; Full Text
A conformational B-cell epitope on the C-terminal end of the extracellular part of human thyroid peroxidase: V. Estienne, et al.; J. Biol. Chem. 273, 8056 (1998), Abstract; Full Text
Current Evaluation of Thyroid Nodules: H. Gharib; Trends Endocrinol. Metab. 5, 365 (1994), Abstract;
Fine-needle aspiration of thyroid follicular neoplasm: diagnostic use of thyroid peroxidase immunocytochemistry with monoclonal antibody 47: C. De Micco, et al.; Surgery 116, 1031 (1994), Abstract;
Malignancy markers in the cytodiagnosis of thyroid nodules. Thyroid peroxidase: C. De Micco, et al.; Ann. Pathol. 14, 378 (1994), Abstract;
Thyroid peroxidase immunodetection as a tool to assist diagnosis of thyroid nodules on fine-needle aspiration biopsy: C. De Micco, et al.; Eur. J. Endocrinol. 131, 474 (1994), Abstract;
Thyroperoxidase immunodetection for the diagnosis of malignancy on fine- needle aspiration of thyroid nodules: J.-F. Henry, et al.; World J. Surg. 18, 529 (1994), Abstract;
Immunohistochemical study of thyroid peroxidase in normal, hyperplastic, and neoplastic human thyroid tissues: C. De Micco, et al.; Cancer 67, 3036 (1991), Abstract;
Relationship between immunological structure and biochemical properties of human thyroid peroxidase: J. Ruf, et al.; Endocrinology 125, 1211 (1989), Abstract;

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