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HSP90α/β monoclonal antibody (H90-10)

 
ALX-804-808-C100 100 µg 269.00 USD
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Product Specification

Alternative Name:Heat shock protein 90α/β, HSP84, Heat shock protein 84
 
Clone:H90-10
 
Host:Mouse
 
Isotype:IgG2a
 
Immunogen:Purified human HSP90β (heat shock protein 90β).
 
UniProt ID:P07900 (HSP90α), P08238 (HSP90β)
 
Species reactivity:Human, Mouse
Rabbit
 
Applications:ICC, IP, WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Works on endogenous.
 
Purity Detail:Purified from concentrated hybridoma tissue culture supernatant.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least one year after receipt when stored as recommended.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Murine breast carcinoma 4T1 cells are more sensitive to atranorin than normal epithelial NMuMG cells in vitro: Anticancer and hepatoprotective effects of atranorin in vivo: P. Solar, et al.; Chem. Biol. Interact. 250, 27 (2016), Application(s): Western blot, Abstract;
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells: T. Zhang, et al.; Mol. Cancer Ther. 7, 162 (2008), Abstract;
GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway: A. Chadli, et al.; Mol. Cell. Biol. 26, 1722 (2006), Abstract;
Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress: S.J. Arlander, et al.; J. Biol. Chem. 278, 52572 (2003), Abstract; Full Text
The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR: O. Donze, et al.; EMBO J. 20, 3771 (2001), Abstract;
The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties: S.J. Felts, et al.; J. Biol. Chem. 275, 3305 (2000), Abstract; Full Text
Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes: R.L. Barent, et al.; Mol. Endocrinol. 12, 342 (1998), Abstract; Full Text
Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome: M.A. Loo, et al.; EMBO J. 17, 6879 (1998), Abstract;

General Literature References

Cancer: the rules of attraction: L. Neckers and Y.S. Lee; Nature 425, 357 (2003), Review, Abstract;
Heat shock protein 90 as a molecular target for cancer therapeutics: J.S. Isaacs, et al.; Cancer Cell 3, 213 (2003), Review, Abstract;
More than folding: localized functions of cytosolic chaperones: J.C. Young, et al.; TIBS 28, 541 (2003), Review, Abstract;

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