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Prolactin receptor monoclonal antibody (U5)

 
ALX-803-005-C100 100 µg 604.00 USD
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Product Specification

Alternative Name:PRL receptor
 
Clone:U5
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Purified rat liver prolactin receptor.
 
UniProt ID:P05710
 
Species reactivity:Human, Rat
Porcine, Rabbit
 
Specificity:Recognizes the extracellular domain of the prolactin receptor.
 
Applications:Flow Cytometry, ICC, IHC (FS), IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Flow Cytometry (FACS)
Immunocytochemistry (5µg/ml)
Immunofluorescence (1:20)
Western Blot (1µg/ml). Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
 
Application Notes:Detects bands of ~40kDa and of ~100kDa representing both the short and the long forms of the prolactin receptor. Does not inhibit the interaction of prolactin with the receptor.
 
Formulation:Lyophilized. Contains 0.05% sodium azide.
 
Reconstitution:Reconstitute with 100µl PBS.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Prolactin (PRL) is a hormone involved in a variety of important functions including ion transport and osmoregulation, stimulation of milk, protein synthesis as well as the regulation of numerous reproductive functions. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor, a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. The PRL receptor consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
 
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Figure: Immunohistochemical staining of PRL receptor in rat Islets of Langerhans using MAb to Prolactin Receptor (U5) (Prod. No. ALX-803-005).
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Product Literature References

The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation: L. De Petrocellis, et al.; PNAS 95, 8375 (1998), Abstract; Full Text
Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation: M. Perrot-Applanat, et al.; J. Cell Sci. 110, 1123 (1997), Abstract; Full Text
The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation: M. Royster, et al.; Endocrinology 136, 3892 (1995), Abstract;
Characterization and applications of monoclonal antibodies to the prolactin receptor: H. Okamura, et al.; Endocrinology 124, 2499 (1989), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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