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RGMC (soluble) (human), (recombinant)

 
ALX-522-104-C010 10 µg 296.00 USD
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Product Specification

Alternative Name:Repulsive guidance molecule C, Hemojuvelin, Hemochromatosis type 2 protein, HFE2
 
Source:Produced in HEK 293 cells. Human RGMC (aa 36-398) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
 
UniProt ID:Q6ZVN8
 
Concentration:0.1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity Detail:Purified by single-step affinity chromatography.
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
 
Reconstitution:Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Scientific Background:The RGMC (also called Hemojuvelin) is an GPI-anchored protein involved in the iron metabolism through regulation of hepcidin expression. Mutations in the gene encoding RGMC cause severe iron overload (juvenile hemochromatosis /hemochromatosis type 2A). The protein binds to neogenin and acts as co-receptor of the bone morphogenetic protein. The mature RGMc protein is proteolytically processed and glycosylated.
 
Technical Info/Product Notes:FLAG is a registered trademark of Sigma-Aldrich Co.
 

General Literature References

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression: J.L. Babitt, et al.; Nat. Genet. 38, 531 (2006), Abstract;
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload: V. Niederkofler, et al.; J. Clin. Invest. 115, 2180 (2005), Abstract;
RGM and its receptor neogenin regulate neuronal survival: E. Matsunaga, et al.; Nat. Cell Biol. 6, 749 (2004), Abstract;

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