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(-)-Menthol

TRP channel activator
 
ALX-420-042-M100 100 mg 82.00 USD
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Cooling agent. Strongly activates TRPM8 (cold menthol receptor 1; CMR1) and TRPA1.

Product Specification

Alternative Name:(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol, 5-Methyl-2-(1-methylethyl)cyclohexanol
 
Formula:C10H20O
 
MW:156.3
 
CAS:2216-51-5
 
MI:14: 5837
 
RTECS:OT0700000
 
Purity:≥98% (sum of enantiomers, GC)
 
Identity:Identity determined by 1H-NMR.
 
Appearance:Colorless to white crystalline solid.
 
Solubility:Soluble in 100% ethanol or methanol (100mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Limited shelf life.
 
420-042
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420-042

Product Literature References

Bimodal action of menthol on the transient receptor potential channel TRPA1: Y. Karashima, et al.; J. Neurosci. 27, 9874 (2007), Abstract;
The menthol receptor TRPM8 is the principal detector of environmental cold: D.M. Bautista, et al.; Nature 448, 204 (2007), Abstract;
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain: C.J. Proudfoot, et al.; Curr. Biol. 16, 1591 (2006), Abstract;
Sensing with TRP channels: T. Voets, et al.; Nat. Chem. Biol. 1, 85 (2005), Review, Abstract;
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH: D.A. Andersson, et al.; J. Neurosci. 24, 5364 (2004), Abstract; Full Text
Identification of a cold receptor reveals a general role for TRP channels in thermosensation: D.D. McKemy, et al.; Nature 416, 52 (2002), Abstract;

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