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BAY 41-2272

Guanylyl cyclase activator
 
ALX-420-030-M005 5 mg 98.00 USD
 
ALX-420-030-M025 25 mg 398.00 USD
Do you need bulk/larger quantities?
 
NO-independent activator of soluble guanylyl cyclase (sGC). Activates both isoforms α1β1 and α1β2 of sGC. While the related compound YC-1 (Prod. No. ALX-420-025) also acts as a non-specific phosphodiesterase inhibitor, BAY 41-2272 has no effect on phosphodiesterases. Stimulation of sGC is not blocked by high concentrations of NO scavengers (e.g. PTIO, Prod. No. ALX-430-007) and the combination of BAY 41-2272 with the NO donor DEA NONOate (Prod. No. ALX-430-034) potentiates the activation of sGC. Although BAY 41-2272 alone is not as strong a stimulator of sGC as NO, concentrations as low as 10-100nM stimulate sGC to a level that would be expected to cause biologically important increases in cGMP. ODQ (Prod. No. ALX-270-034), a potent and selective inhibitor of sGC, completely inhibited the effect of BAY 41-2272. The activity of BAY 41-2272 is described in selected literature references.

Product Specification

Alternative Name:3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine
 
Formula:C20H17FN6
 
MW:360.4
 
CAS:256376-24-6
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white needles.
 
Solubility:Soluble in DMSO, dichloromethane, 100% ethanol or 2-pyrrolidone; practically insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
420-030
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420-030

Product Literature References

FOXO3 is essential for CD44 expression in pancreatic cancer cells: M. Kumazoe, et al.; Oncogene (2016), Abstract;
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice: R. Thoonen, et al.; Nat. Commun. 6, 8482 (2015), Application(s): Cell Culture, Abstract;
BAY 41-2272, a soluble guanylate cyclase agonist, activates human mononuclear phagocytes: P.V. Soeiro-Pereira, et al.; Br. J. Pharmacol. 166, 1617 (2012), Abstract; Full Text
Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice: E.P. Schmidt, et al.; Am. J. Physiol. Lung Cell. Mol. Physiol. 295, (2008), Abstract;
Identification of residues crucially involved in soluble guanylate cyclase activation: C. Rothkegel, et al.; FEBS Lett. 580, 4205 (2006), Abstract;
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment: A. Ahluwalia, et al.; PNAS 101, 1386 (2004), Abstract; Full Text
BAY 41-2272: a stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivo: E. Bischoff, et al.; Urology 61, 464 (2003), Abstract;
Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure: G. Boerrigter, et al.; Circulation 107, 686 (2003), Abstract;
Macrophage endothelial nitric oxide synthase auto-regulates cellular activation and pro-inflammatory protein expression: L. Connelly, et al.; J. Biol. Chem. 278, 26480 (2003), Abstract; Full Text
BAY 41-2272 activates two isoforms of nitric oxide-sensitive guanylyl cyclase: M. Koglin, et al.; BBRC 292, 1057 (2002), Abstract;
NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272: E.M. Becker, et al.; BMC Pharmacol. 1, 13 (2001), Abstract; Full Text
NO-independent regulatory site on soluble guanylate cyclase: J.P. Stasch, et al.; Nature 410, 212 (2001), Abstract;
NO-independent stimulators of soluble guanylate cyclase: A. Straub, et al.; Bioorg. Med. Chem. Lett. 11, 781 (2001), Abstract;

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