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YC-1

Guanylyl cyclase activator



ALX-420-025-M001	1 mg	45.00 USD

ALX-420-025-M005	5 mg	90.00 USD
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Replaces Prod. #: BML-CN223

Nitric oxide (NO) independent, superoxide-sensitive stimulator of soluble guanylyl cyclase (sGC), EC₅₀=18.6μM. Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. Non-specific phosphodiesterase inhibitor. YC-1 inhibits HIF-α activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth. Inhibits Na⁺ channel.Binds to [³H]BW202W92.

Product Details

Formula:	C₁₉H₁₆N₂O₂

MW:	304.4

CAS:	170632-47-0

Purity:	≥98% (HPLC)

Identity:	Identity determined by ¹H-NMR.

Appearance:	White to pale yellow powder.

Solubility:	Soluble in DMSO, methanol or dichloromethane.

Shipping:	Ambient Temperature

Long Term Storage:	+4°C

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Expression of N-WASP is regulated by HiF1α through the hypoxia response element in the N-WASP promoter: A. Salvi & T. Thanabalu; Biochem. Biophys. Rep. 9, 13 (2016), Abstract; Full Text

Selection, Analysis and Improvement of Anti-Angiogenesis Compounds Identified by an Anti-HIF-1α Screening and Validation System: C. Madu, et al.; J. Cancer 7, 1926 (2016), Application(s): Screening for anti-HIF-1α compounds and chemical modification of the lead compound G3, Abstract; Full Text

A Novel Drug Binding Site on Voltage-Gated Sodium Channels in Rat Brain: D. R. Riddall, et al.; Mol. Pharmacol. 69, 278 (2006), Abstract;

Soluble guanylyl cyclase activator YC-1 protects white matter axons from nitric oxide toxicity and metabolic stress, probably through Na(+) channel inhibition: G. Garthwaite, et al.; Mol. Pharmacol. 61, 97 (2002), Abstract;

Generation and characterization of a stable soluble guanylate cyclase-overexpressing CHO cell line: E.M. Becker, et al.; Nitric Oxide 3, 55 (1999), Abstract;

Mechanism of YC-1-induced activation of soluble guanylyl cyclase: A. Friebe & D. Koesling; Mol. Pharmacol. 53, 123 (1998), Abstract; Full Text

Nitric oxide-sensitive guanylyl cyclase inhibits acetylcholine release and excitatory motor transmission in the guinea-pig ileum: K. Hebeiss & H. Kilbinger; Neuroscience 82, 623 (1998), Abstract;

Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide: J.R. Stone & M.A. Marletta; Chem. Biol. 5, 255 (1998), Abstract;

Activation of soluble guanylyl cyclase by YC-1 in aortic smooth muscle but not in ventricular myocardium from rat: J.W. Wegener, et al.; Br. J. Pharmacol. 122, 1523 (1997), Abstract;

Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle: J.W. Wegener & H. Nawrath; Eur. J. Pharmacol. 323, 89 (1997), Abstract;

Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators: A. Mülsch, et al.; Br. J. Pharmacol. 120, 681 (1997), Abstract;

Inhibition of platelet adhesion to collagen by cGMP-elevating agents: C.C. Wu, et al.; BBRC 231, 412 (1997), Abstract;

YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase: C.C. Wu, et al.; Br. J. Pharmacol. 116, 1973 (1995), Abstract;

YC-1, a novel activator of platelet guanylate cyclase: F.N. Ko, et al.; Blood 84, 4226 (1994), Abstract;

General Literature References

YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1: E.J. Yeo, et al.; J. Natl. Cancer Inst. 95, 516 (2003), Abstract;

Inhibition of extracellular Ca(2+) entry by YC-1, an activator of soluble guanylyl cyclase, through a cyclic GMP-independent pathway in rat neutrophils: J.P. Wang, et al.; Biochem. Pharmacol. 62, 679 (2001), Abstract;

Molecular mechanisms involved in the synergistic activation of soluble guanylyl cyclase by YC-1 and nitric oxide in endothelial cells: K. Schmidt, et al.; Mol. Pharmacol. 59, 220 (2001), Abstract;

Prolonged exposure to YC-1 induces apoptosis in adrenomedullary endothelial and chromaffin cells through a cGMP-independent mechanism: R. Ferrero & M. Torres; Neuropharmacology 41, 895 (2001), Abstract;

YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components: E. Martin, et al.; Proc. Natl. Acad. Sci. USA 98, 12938 (2001), Abstract;