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Enniatin A1

Ionophore antibiotic
 
ALX-380-311-M001 1 mg 163.00 USD
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Ionophore antibiotic. Induces apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation.

Product Specification

Formula:C35H61N3O9
 
MW:667.9
 
Source:Isolated from Fusarium sp.
 
CAS:4530-21-6
 
Purity:≥97% (HPLC)
 
Identity:Identity determined by 1H-NMR, 13C-NMR and MS.
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in 100% ethanol, methanol, DMSO and dimethyl formamide; almost insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Scientific Background:Enniatins are a family of depsipeptides produced by several species of the filamentous fungus Fusarium. Enniatins have initially been shown to act as ionophores. Later, their effects on acyl-CoA cholesterol transferase, ABC-transporters and the selectivity of their antitumor action came to the fore.
 
380-311
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380-311

Product Literature References

Fate of Fusarium Toxins during Brewing: K. Habler, et al.; J. Agric. Food Chem. 64, 190 (2017), Abstract;
Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation: W. Wätjen et al.; Mol. Nutr. Food Res. 53, 431 (2009), Abstract;
Interactions between ABC-transport proteins and the secondary Fusarium metabolites enniatin and beauvericin: R. Dornetshuber et al.; Mol. Nutr. Food Res. 53, 904 (2009), Abstract;
Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction: R. Dornetshuber et al.; Mol. Nutr. Food Res. 53, 1112 (2009), Abstract;
Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells: R. Dornetshuber, et al.; Chem. Res. Toxicol. 20, 465 (2007), Abstract;
Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum: L. Ivanova et al.; Toxicon 47, 868 (2006), Abstract;
Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae: K. Hiraga, et al.; BBRC 328, 1119 (2005), Abstract;
Interaction of cyclic peptides and depsipeptides with calmodulin: K.A. Mereish, et al.; Pept. Res. 3, 233 (1990), Abstract;
"Sandwich" complexation in cyclopeptides and its implications in membrane processes: V.T. Ivanov; Ann. N. Y. Acad. Sci. 264, 221 (1975), Abstract;
Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria: E. Gaumann, et al.; Experientia 3, 202 (1947),

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