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Psoralen

 
ALX-350-364-M025 25 mg 110.00 USD
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Shows antiviral, antibacterial, antifungal and insecticidal properties. Binds DNA through single and double-stranded cross-linking after photoactivation. Used as photochemical probe in studies of DNA mutation and repair mechanisms. Causes photosensitization in human.

Product Specification

Alternative Name:Ficusin, 7H-Furo[3,2-g]benzopyran-7-one
 
Formula:C11H6O3
 
MW:186.2
 
Source:Isolated from Psoralea corylifolia.
 
CAS:66-97-7
 
MI:14: 7928
 
RTECS:LV0944000
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in ethyl acetate or acetone; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
350-364
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350-364

Product Literature References

CYP3A4 inhibition by Psoralea corylifolia and its major components in human recombinant enzyme, differentiated human hepatoma HuH-7 and HepaRG cells: Y. Liu, et al.; Toxicol. Rep. 2, 530 (2015), Application(s): Cell Culture ,
Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells: S. Couve-Privat, et al.; Nucl. Acids Res. 35, 5672 (2007), Abstract; Full Text
Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids: K.H. Kim, et al.; Nucl. Acids Res. 35, 7604 (2007), Abstract; Full Text
Psoralen photocrosslinking, a tool to study the chromatin structure of RNA polymerase I--transcribed ribosomal genes: M. Toussaint, et al.; Biochem. Cell Biol. 83, 449 (2005), Abstract;
DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria: C. Cullinane & V.A. Bohr; Cancer Res. 58, 1400 (1998), Abstract; Full Text
Probing DNA structure with psoralen in vitro: D.W. Ussery, et al.; Meth. Enzymol. 212, 242 (1992), Abstract;
Electron microscopic identification of supercoiled regions in complex DNA structures: R.B. Inman & M. Schnos; J. Mol. Biol. 193, 377 (1987), Abstract;
Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry: G.D. Cimino, et al.; Annu. Rev. Biochem. 54, 1151 (1985), (Review), Abstract;
Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig: A. Kornhauser, et al.; Science 217, 733 (1982), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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