- Highly pure Ganglioside GQ1b isolated from bovine brain
- Used for the differentiation of a variety of cells
Gangliosides consist of a ceramide moiety, an oligosaccharide head group, and one or more sialic acids. They are involved in a variety of cellular functions acting as cell adhesion receptors and immunological receptors via the binding of lectins; contributing to cell differentiation, cell signaling, and oncogenesis; participating in myelin stability and nerve regeneration; and operating as an entry point for toxins and viruses. Ganglioside GT1b consists of a tetra-saccharide core with two sialic acid on the internal galactose and an extra sialic acid on the non-reducing terminal galactose. Ganglioside GT1b prevents neurotoxicity of glutamate on neuronal cells and binds to the neurotoxins Botulinum Toxin serotype A (BTxA), BTxA heavy chain, and Tetanus Toxin with respective IC50 values of 11, 0.74, and 7.2 µM. Treatment of human PBMC with Ganglioside GT1b is associated with a decrease in IgA, IgG, IgM, IL-6, and IL-10 levels.
Product Details
| Alternative Name: | GT1b . 3Na (bovine brain), Trisialoganglioside GT1b . 3Na (bovine brain) |
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| Sequence: | [II3(Neu5Ac)2, IV3(Neu5Ac)GgOse4Cer] [[α-Neu5Ac-(2→3)]-β-Gal(1→3)-β-GalNAc-(1→4)-[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1')-Cer] |
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| Formula: | C95H162N5O47 . 3Na |
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| MW: | 2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid) |
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| Source: | Bovine brain |
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| CAS: | 59247-13-1 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Confirmed by MS. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in chloroform/methanol/DI water, 2:1:0.1; forms micellar solution in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA: D.C. Rupp, et al.; Clin. Cosmet. Investig. Dermatol.
16, 581 (2023),
Abstract;
Anti-inflammatory role of GM1 and other gangliosides on microglia: D. Galleguillos, et al.; J. Neuroinflammation
19, 9 (2022),
Abstract;
Full Text
Characterization of clostridium botulinum neurotoxin serotype A (BoNT/A) and fibroblast growth factor receptor interactions using novel receptor dimerization assay: N.G. James, et al.; Sci. Rep.
11, 7832 (2021),
Abstract;
Full Text
A dual-ligand fusion peptide improves the brain-neuron targeting of nanocarriers in Alzheimer's disease mice: Q. Guo, et al.; J. Control Release
320, 347 (2020),
Abstract;
Retargeting the Clostridium botulinum C2 toxin to the neuronal cytosol: B.J. Pavlik, et al.; Sci. Rep.
6, 23707 (2016),
Abstract;
Full Text
GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons: E.S. Chung, et al.; BMC Neurosci.
11, 74 (2010),
Abstract;
Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex: M. Favaron, et al.; PNAS
85, 7351 (1988),
Abstract;
General Literature References
Botulinum neurotoxin: a marvel of protein design: M. Montal; Annu. Rev. Biochem.
79, 591 (2010),
Abstract;
Full Text
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