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Ganglioside GT1b . trisodium salt (bovine brain)

 
ALX-302-011-M001 1 mg 105.00 USD
 
ALX-302-011-M005 5 mg 336.00 USD
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Prevents neurotoxicity of glutamate on neuronal cells.

Product Specification

Alternative Name:GT1b . 3Na (bovine brain), Trisialoganglioside GT1b . 3Na (bovine brain)
 
Sequence:[II3(Neu5Ac)2, IV3(Neu5Ac)GgOse4Cer] [[α-Neu5Ac-(2→3)]-β-Gal(1→3)-β-GalNAc-(1→4)-[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1→1')-Cer]
 
Formula:C95H162N5O47 . 3Na
 
MW:2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid)
 
CAS:59247-13-1
 
Purity:≥98% (TLC)
 
Appearance:Lyophilized.
 
Solubility:Very soluble in water, biological buffers, 100% ethanol or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
ALX-302-011
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ALX-302-011

Product Literature References

GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons: E.S. Chung, et al.; BMC Neurosci. 11, 74 (2010), Abstract;
Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex: M. Favaron, et al.; PNAS 85, 7351 (1988), Abstract;

General Literature References

Botulinum neurotoxin: a marvel of protein design: M. Montal; Annu. Rev. Biochem. 79, 591 (2010), Abstract; Full Text

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