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Indirubin

Inhibitor of CDK and GSK
 
ALX-270-361-M001 1 mg 55.00 USD
 
ALX-270-361-M005 5 mg 240.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-CC206

Inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC50=10µM), CDK2/cyclin A (IC50=2.2µM), CDK2/cyclin E (IC50=7.5µM), CDK4/cyclin D1 (IC50=12µM), CDK5/p35 (IC50=5.5µM)) and of GSK-3β (IC50=600nM). Inhibits inflammatory reaction in delayed-type hypersensitivity in mice. Ligand of human aryl hydrocarbon receptor. Exhibits anti-cancer activity.

Product Specification

Formula:C16H10N2O2
 
MW:262.3
 
Source:Synthetic.
 
CAS:479-41-4
 
Purity:≥98% (1H-NMR, HPLC)
 
Appearance:Purple powder.
 
Solubility:Soluble in DMSO (10mg/ml) or methanol (0.3mg/ml); sparingly soluble in aqueous buffers (12.5µg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Stable for at least 2 years when stored at +4°C in the dark. Stock solutions should be stored in the dark and used within 1 month.
 
Handling:Protect from light. Keep cool and dry.
 
Scientific Background:Indirubin is derived from various natural sources, such as Indigofera indica, Isatis tinctoria and I. indigotica by fermentation, oxidation and the presence of light as a by product of indigo formation. Indirubin is also present in human urine and fetal bovine serum. Preclinical studies of indirubin confirmed its anti-tumor activity. Efficacy against chronic myelocytic leukemia was demonstrated in clinical trials in China.
 
270-361
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270-361

Product Literature References

Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway: G. Sethi, et al.; J. Biol. Chem. 281, 23425 (2006), Abstract;
Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine: G. Eisenbrand, et al.; J. Cancer Res. Clin. Oncol. 130, 627 (2004), Abstract;
Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine: J. Adachi, et al.; J. Biol. Chem. 276, 31475 (2001), Abstract; Full Text
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?: S. Leclerc, et al.; J. Biol. Chem. 276, 251 (2001), Abstract; Full Text
Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity: T. Kunikata, et al.; Eur. J. Pharmacol. 410, 93 (2000), Abstract;
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases: R. Hoessel, et al.; Nature Cell Biol. 1, 60 (1999), Abstract;

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