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Inibitor of phosphoinositide-dependent kinase 1 and GSK
ALX-430-156-M001 1 mg 88.00 USD
ALX-430-156-M005 5 mg 172.00 USD
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Inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β) (IC50=5nM). Maintains self-renewal and pluripotency in embryonic stem cells via activation of Wnt in vitro. Promotes proliferation and dedifferentiation in cardiomyocytes.

Product Details

Purity:≥98% (HPLC)
Appearance:Dark red solid.
Solubility:Soluble in DMSO.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Adipose-derived mesenchymal stem cells promote salivary duct regeneration via a paracrine effect: S. Kang, et al.; J. Oral. Biosci. 65, 104 (2023), Abstract;
Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL: Y.A. Albalawi, et al.; Viruses 14, 1469 (2022), Abstract;
Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production: A. Valerio, et al.; J. Neurochem. 116, 1148 (2011), Abstract;
Anticancer effects and antimetastatic mechanisms of novel indirubin derivatives: C.A. Kressirer; (2010), (PhD thesis), Full Text
Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover: R. Yasuhara, et al.; J. Biol. Chem. 285, 317 (2010), Abstract; Full Text
Inhibition of glycogen synthase kinase-3beta downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A: L. Martin, et al.; Brain Res. 1252, 66 (2009), Abstract;
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007), Abstract;
Inverse in silico screening for identification of kinase inhibitor targets: S. Zahler, et al.; Chem. Biol. 14, 1207 (2007), Abstract;
7-Bromoindirubin-3’-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006), Abstract;
The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes: A.S. Tseng, et al.; Chem. Biol. 13, 957 (2006), Abstract;
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem. 47, 935 (2004), Abstract;
GSK-3-selective inhibitors derived from Tyrian purple indirubins: L. Meijer, et al.; Chem. Biol. 10, 1255 (2003), Abstract;

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