Inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β) (IC50=5nM). Maintains self-renewal and pluripotency in embryonic stem cells via activation of Wnt in vitro. Promotes proliferation and dedifferentiation in cardiomyocytes.
Product Details
| Formula: | C16H10BrN3O2 |
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| MW: | 356.2 |
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| CAS: | 667463-62-9 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Dark red solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL: Y.A. Albalawi, et al.; Viruses
14, 1469 (2022),
Abstract;
Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production: A. Valerio, et al.; J. Neurochem.
116, 1148 (2011),
Abstract;
Anticancer effects and antimetastatic mechanisms of novel indirubin derivatives: C.A. Kressirer; (2010), (PhD thesis),
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Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover: R. Yasuhara, et al.; J. Biol. Chem.
285, 317 (2010),
Abstract;
Full Text
Inhibition of glycogen synthase kinase-3beta downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A: L. Martin, et al.; Brain Res.
1252, 66 (2009),
Abstract;
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem.
50, 4027 (2007),
Abstract;
Inverse in silico screening for identification of kinase inhibitor targets: S. Zahler, et al.; Chem. Biol.
14, 1207 (2007),
Abstract;
7-Bromoindirubin-3’-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene
25, 6304 (2006),
Abstract;
The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes: A.S. Tseng, et al.; Chem. Biol.
13, 957 (2006),
Abstract;
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem.
47, 935 (2004),
Abstract;
GSK-3-selective inhibitors derived from Tyrian purple indirubins: L. Meijer, et al.; Chem. Biol.
10, 1255 (2003),
Abstract;
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