Potent inhibitor of GSK-3β (IC50=9nM). Also inhibits CDK1/cyclin B (IC50=25nM) and CDK5/p25 (IC50=20nM) by binding to the ATP-binding pocket.
Product Details
| Formula: | C16H10IN3O2 |
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| MW: | 403.2 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by 1H-NMR and 13C-NMR. |
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| Appearance: | Dark red solid. |
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| Solubility: | Soluble in DMSO (1M). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?: S. Leclerc, et al.; J. Biol. Chem.
276, 251 (2001),
Abstract;
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