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Phenylmethylsulfonyl fluoride

Inhibitor of serine proteases and FAAH
 
ALX-270-184-G005 5 g 59.00 USD
 
ALX-270-184-G025 25 g 158.00 USD
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Irreversible inhibitor of serine proteases. Widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity. Spleen membranes used for CB2 studies do not require this pretreatment, as FAAH activity is absent in these cells. Inhibits also cysteine proteases like papain (reversible by DTT treatment, Prod. No. ALX-280-001), as well as internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor see AEBSF (Prod. No. ALX-270-022).

Product Specification

Alternative Name:PMSF, Benzylsulfonyl fluoride
 
Formula:C7H7FO2S
 
MW:174.2
 
CAS:329-98-6
 
RTECS:XT8040000
 
Purity:≥99% (Assay (GC-FID))
 
Appearance:White to off-white needle crystals.
 
Solubility:Soluble in 100% ethanol, methanol or isopropanol; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
ALX-270-184
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ALX-270-184

Product Literature References

Identification of Novel Mutations in the LRR-Cap Domain of C21orf2 in Japanese Patients With Retinitis Pigmentosa and Cone-Rod Dystrophy: A. Suga, et al.; Invest. Ophthalmol. Vis. Sci. 57, 4255 (2016), Application(s): Western blot, isolated retina lysates, Abstract; Full Text
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies: I. Albrecht, et al.; J. Clin. Invest. 125, 4612 (2015), Application(s): Skeletal muscle cell culture, Abstract; Full Text
Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist: D.G. Deutsch & S.A. Chin; Biochem. Pharmacol. 46, 791 (1993), Abstract;
Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers: G.T. James; Anal. Biochem. 86, 574 (1978), Abstract;
Kinetic analysis of differences in brain acetylcholinesterase from fish or mammalian sources: D.E. Moss & D.E. Fahrney; Biochem. Pharmacol. 27, 2693 (1978), Abstract;

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