DTT

Protective agent for SH groups



ALX-280-001-G005	5 g	108.00 USD

ALX-280-001-G010	10 g	184.00 USD

ALX-280-001-G025	25 g	331.00 USD

ALX-280-001-G050	50 g	540.00 USD
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Cell permeable protective agent for SH groups, maintaining monothiols completely in the reduced state and of reducing disulfides quantitatively. ER-stress inducer.

Product Details

Alternative Name:	1,4-Dithio-DL-threitol, DL-Dithiothreitol, Cleland's Reagent

Formula:	C₄H₁₀O₂S₂

MW:	154.3

CAS:	3483-12-3

MI:	14: 3376

RTECS:	EK1610000

Purity:	≥98% (Assay by Iodometric Titration)

Identity:	Determined by IR.

Appearance:	White to off-white solid.

Solubility:	Soluble in water, 100% ethanol, acetone or ethyl acetate.

Shipping:	Ambient Temperature

Long Term Storage:	+4°C

Handling:	Very hygroscopic. Keep under inert gas.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Adrenomedullin and truncated peptide adrenomedullin(22-52) affect chondrocyte response to apoptotis in vitro: downregulation of FAS protects chondrocyte from cell death: F. Velard, et al.; Sci. Rep. 10, 16740 (2020), Abstract; Full Text

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells: M. McNaughton, et al.; Oncotarget 7, 16663 (2016), Application(s): Western blot, Abstract; Full Text

Protein tyrosine phosphatase 1B and α-glucosidase inhibitory activities of Pueraria lobata root and its constituents: S.H. Seong, et al.; J. Ethnopharmacol. 194, 706 (2016), Application(s): Inhibitory activity and enzyme kinetic analysis, coral, Abstract;

F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7: Y. Liu, et al.; Cell Death Dis. 6, e1630 (2015), Application(s): Assay, Abstract; Full Text

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy: L. Qin, et al.; Autophagy 6, 239 (2010), Abstract;

Cleland's reagents block lethal and hypnotic effects of pentobarbital: L. Gailis; Eur. J. Pharmacol. 292, 39 (1994), Abstract;

Molecular mechanism for prevention of N-acetyl-p-benzoquinoneimine cytotoxicity by the permeable thiol drugs diethyldithiocarbamate and dithiothreitol: V.V.M. Lauriault & P.J. O'Brien; Mol. Pharmacol. 40, 125 (1991), Abstract;

Enzyme activity and sulfhydryl status in rat renal cortex following mercuric chloride and dithiothreitol administration: D.R. Klonne & D.R. Johnson; Toxicol. Lett. 42, 199 (1988), Abstract;

Dithiothreitol, A New Protective Reagent For SH Groups: W.W. Cleland; Biochemistry 3, 480 (1964), Abstract;