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Protective agent for SH groups
ALX-280-001-G005 5 g 111.00 USD
ALX-280-001-G010 10 g 189.00 USD
ALX-280-001-G025 25 g 340.00 USD
ALX-280-001-G050 50 g 556.00 USD
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Cell permeable protective agent for SH groups, maintaining monothiols completely in the reduced state and of reducing disulfides quantitatively. ER-stress inducer.

Product Details

Alternative Name:1,4-Dithio-DL-threitol, DL-Dithiothreitol, Cleland's Reagent
MI:14: 3376
Purity:≥98% (Assay by Iodometric Titration)
Identity:Determined by IR.
Appearance:White to off-white solid.
Solubility:Soluble in water, 100% ethanol, acetone or ethyl acetate.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:Very hygroscopic. Keep under inert gas.
Regulatory Status:RUO - Research Use Only
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Product Literature References

A mannosylated polymer with endosomal release properties for peptide antigen delivery: K. Song, et al.; J. Control Release 356, 232 (2023), Abstract;
Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma: K.D. Koh, et al.; Cell Genom. 3, 100229 (2022), Abstract;
Adrenomedullin and truncated peptide adrenomedullin(22-52) affect chondrocyte response to apoptotis in vitro: downregulation of FAS protects chondrocyte from cell death: F. Velard, et al.; Sci. Rep. 10, 16740 (2020), Abstract; Full Text
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells: M. McNaughton, et al.; Oncotarget 7, 16663 (2016), Application(s): Western blot, Abstract; Full Text
Protein tyrosine phosphatase 1B and α-glucosidase inhibitory activities of Pueraria lobata root and its constituents: S.H. Seong, et al.; J. Ethnopharmacol. 194, 706 (2016), Application(s): Inhibitory activity and enzyme kinetic analysis, coral, Abstract;
F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7: Y. Liu, et al.; Cell Death Dis. 6, e1630 (2015), Application(s): Assay, Abstract; Full Text
ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy: L. Qin, et al.; Autophagy 6, 239 (2010), Abstract;
Cleland's reagents block lethal and hypnotic effects of pentobarbital: L. Gailis; Eur. J. Pharmacol. 292, 39 (1994), Abstract;
Molecular mechanism for prevention of N-acetyl-p-benzoquinoneimine cytotoxicity by the permeable thiol drugs diethyldithiocarbamate and dithiothreitol: V.V.M. Lauriault & P.J. O'Brien; Mol. Pharmacol. 40, 125 (1991), Abstract;
Enzyme activity and sulfhydryl status in rat renal cortex following mercuric chloride and dithiothreitol administration: D.R. Klonne & D.R. Johnson; Toxicol. Lett. 42, 199 (1988), Abstract;
Dithiothreitol, A New Protective Reagent For SH Groups: W.W. Cleland; Biochemistry 3, 480 (1964), Abstract;

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