Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

γ-Secretase inhibitor

ALX-260-127-M001 1 mg 351.00 USD
Do you need bulk/larger quantities?
Reversible peptidomimetic inhibitor of γ-secretase (IC50=10-25µM for total β-amyloid), presenilinase (IC50=0.1-1µM), and calpain II (IC50=100µM).

Product Specification

Alternative Name:MW167
Solubility:Soluble in DMSO containing 10% water.
Long Term Storage:-20°C
Use/Stability:Stock solutions in DMSO are stable for 6 months when stored at -20°C.
Handling:Protect from moisture.
ALX-260-127 structure
Please mouse over
ALX-260-127 structure

Product Literature References

Notch1 signaling is mediated by importins alpha 3, 4, and 7: K. Huenniger, et al.; Cell. Mol. Life Sci. 67, 3187 (2010), Abstract;
DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries: I. Sorensen, et al.; Blood 113, 5680 (2009), Abstract;
Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase: E.L. Meyer, et al.; J. Biol. Chem. 278, 23786 (2003), Abstract; Full Text
Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase: W.A. Campbell, et al.; J. Neurochem. 85, 1563 (2003), Abstract;
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease: M.S. Wolfe, et al.; Biochemistry 38, 4720 (1999), Abstract;
A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity: M.S. Wolfe, et al.; J. Med. Chem. 41, 6 (1998), Abstract;
Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities: M. Citron, et al.; PNAS 93, 13170 (1996), Abstract; Full Text

Related Literature

Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

All new literature pieces

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2019 Enzo Life Sciences, Inc.,