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GPCR pain, Ab sample pack

 
ADI-PAK-110 5x25 µg 345.00 USD
Do you need bulk/larger quantities?
 
Antibody sample packs are designed to be cost effective and help you choose which of our many antibodies might work best for your particular sample type or application. This antibody sample pack includes a set of related GPCR polyclonal antibodies for pain research.

Product Specification

Applications:ELISA, IHC, WB
 
Application Notes:Application varies by product.
 
Kit/Set Contains:Contains 25µg each of the following Abs:
Cannabinoid receptor CB1, pAb (Prod. No. ADI-905-708)
Cannabinoid receptor CB2, pAb (Prod. No. ADI-905-749)
Opioid receptor μ, pAb (Prod. No. ADI-905-744)
Opioid receptor δ, pAb (Prod. No. ADI-905-745)
Opioid receptor κ, pAb (Prod. No. ADI-905-799)
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The cannabinoid receptors CB1 and CB2 are GPCRs named for their signaling function in response to cannabinoid drugs such as Delta9-tetrahydrocannabinol (Delta9-THC). In addition to Delta9-THC and its synthetic analogs, CB1 and CB2 receptors are bound by endogenous eicosanoid ligands (e.g. anandamide), and signal via Gi/o alpha subunits to regulate adenylyl cyclase activity (generally inhibitory), ion channel activation, intracellular Ca2+ levels, nitric oxide synthase activation, and immediate early gene expression. CB1 and CB2 signals in turn regulate neurological and immunological functions such as inhibition of neurotransmitter release and immune cell migration, antigen processing, and cytokine production.The opioid receptors delta (DOP, OP1), kappa (KOP, OP2), and mu (MOP, OP3) are GPCRs that share ~60% identity, but vary greatly in the extracellular N-terminus region of the receptors. The delta, kappa and mu-receptors serve as functional receptors for endogenous enkephalin, dynorphin, and beta-endorphin peptide ligands, respectively. Delta-opioid receptors function to inhibit neurotransmitter release resulting in a variety of biological effects including analgesia, motor integration, gastro-intestinal motility, olfaction, respiration, and memory. Kappa-opioid receptors are found in the cerebral cortex, nucleus accumbens, claustrum, and hypothalamus, and are known to regulate nociception, diuresis, feeding, as well as immune and neuroendocrine function. The mu-receptor typically functions as a depressant in physiological processes including respiration, cardiovascular function, gastrointestinal motility, and thermoregulation.
 

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Cannabinoid receptor CB1 polyclonal antibody 

ELISA, IHC, WB | Print as PDF
 
ADI-905-708-100 100 µg 301.00 USD
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Cannabinoid receptor CB2 polyclonal antibody 

ELISA, IHC, WB | Print as PDF
 
ADI-905-749-100 100 µg 291.00 USD
Do you need bulk/larger quantities?
 

Opioid receptor μ polyclonal antibody 

ELISA, IHC, WB | Print as PDF
 
ADI-905-744-100 100 µg 301.00 USD
Do you need bulk/larger quantities?
 

Opioid receptor δ polyclonal antibody 

ELISA, IHC, WB | Print as PDF
 
ADI-905-745-100 100 µg 301.00 USD
Do you need bulk/larger quantities?
 

Opioid receptor κ polyclonal antibody 

ELISA, IHC, WB | Print as PDF
 
ADI-905-799-100 100 µg 301.00 USD
Do you need bulk/larger quantities?
 

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For Research Use Only. Not for use in diagnostic procedures.
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