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p53 polyclonal antibody

 
ADI-KAP-CC030-G 250 µg 313.00 USD
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Product Specification

Alternative Name:TRP53, Tumor protein p53
 
Host:Sheep
 
Immunogen:Recombinant human p53 (aa 1-393).
 
UniProt ID:P04637
 
Species reactivity:Human, Mouse, Rat
 
Applications:IHC, IP, WB
 
Recommended Dilutions/Conditions:Western Blot (1-10µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~53kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.08% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to Mdm2, SV40 T antigen and human Papilloma virus E6 protein. p53 senses DNA damage and facilitates its repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovary, bladder, colon, lung, and melanoma.
 

Product Literature References

Prognostic impact and targeting of CRM1 in acute myeloid leukemia: K. Kojima, et al.; Blood 121, 4166 (2013), Abstract;

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