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TRAIL-R3 polyclonal antibody

 
ADI-905-216-100 100 µg 366.00 USD
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Product Specification

Alternative Name:TRAIL receptor 3, DcR1, Death Receptor 1, TRID, CD263, TNFRSF 10C, TNF-related apoptosis-inducing ligand receptor 3, Tumor necrosis factor receptor superfamily member 10C
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of the extracellular domain of human TRAIL-R3.
 
UniProt ID:O14798
 
Gene/Protein Identifier:8794 (Entrez GeneID)
 
Species reactivity:Human, Mouse, Rat
 
Applications:ICC, WB
 
Recommended Dilutions/Conditions:Western Blot (1:500-1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~65kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Decoy receptors (DcRs) are signaling-deficient receptors for certain members of the TNF family of cytokines, including TRAIL/Apo2L and FasL. Functional TRAIL receptors such as DR4 and DR5 transmit apoptotic signals via their intracellular death domains. In contrast, three identified TRAIL decoy receptors (DcR1, DcR2, and osteoprotegerin/OPG) completely or partially lack the signaling death domain, and/or are secreted from cells and unable to transmit intracellular signals. Thus, expression of DcRs promotes survival by sequestration of apoptotic ligands. A fourth identified decoy receptor, DcR3, binds both FasL and the vascular endothelial cell growth inhibitor (VEGI), inhibiting Fas and DR3 death signals.
 
905-216 WB
Western blot analysis of DcR1 in HeLa whole cell lysate with DcR1 antibody (ED) at 1:500 dilution.
905-216 ICC
Immunocytochemistry analysis of DcR1 in HeLa cells with DcR1 antibody at 10µg/ml.
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905-216 WB 905-216 ICC

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