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Dkk-1 (human), ELISA kit

First-to-market Dkk-1 ELISA commercially available for wnt signaling pathway research.
 
ADI-900-151 96 wells 394.00 USD
Do you need bulk/larger quantities?
 
  • Easy-to-use - ready-to-use liquid color-coded reagents reduce errors
  • Higher throughput - reproducible results from up to 39 samples in duplicate in just 3 hours
  • Trusted - validated with pathological and non-pathological samples
The Dkk-1 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours. Absorbance is read at 450 nm. The Dkk-1 (human), EIA kit offers ultra-sensitive and accurate measurement of Dickkopf-1 and has been validated in-house in normal and pathological samples.
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Product Specification

Alternative Name:Dickkopf-1
 
Sensitivity:0.98 pg/ml (range 7.81-500 pg/ml)
 
Assay Time:3 hours
 
Applications:ELISA, Colorimetric detection
 
Application Notes:For the quantitative determination of human Dkk-1 in culture supernatants, plasma, and serum.
 
Species reactivity:Human
 
Use/Stability:Store all components at +4°, except standard at -20°.
 
Shipping:Shipped on Blue Ice
 
Kit/Set Contains:Microtiter plate, Conjugate, Antibody, Assay buffer 10 Concnetrate, Wash buffer concentrate, Standard, TMB Substrate, Stop solution 2
 
Scientific Background:Dkk-1 (Dickkopf-1) is a secreted inhibitor of the canonical Wnt signaling pathway, which mediates a variety of cellular processes including the growth and development of osteoblasts. Dkk-1 disrupts the canonical pathway by binding to the LRP5/6 co-receptors, preventing interaction with Wnt, and facilitating the degradation of beta-catenin. Dkk-1 is overexpressed in multiple myeloma, increasing bone resorption and the appearance of osteolytic lesions characteristic of multiple myeloma.
 
UniProt ID:O94907
 

Product Literature References

Fewer bone disease events, improvement in bone remodeling, and evidence of bone healing with bortezomib plus melphalan-prednisone vs. melphalan-prednisone in the phase III VISTA trial in multiple myeloma: M. Delforge, et al.; Eur. J. Haematol. 86, 372 (2011), Application(s): EIA using human serum, Abstract;
Lack of diagnostic potential of Dickkopf-1 in colon and rectum cancers: H.O. Soydinc, et al.; Asian Pac. J. Cancer. Prev. 12, 3187 (2011), Application(s): EIA using human serum, Abstract; Full Text
The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis: A.M. Betts, et al.; J. Pharmacol. Exp. Ther. 333, 2 (2010), Application(s): EIA using human serum, Abstract; Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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