Name | Synonyms | Entrez Gene ID | SwissProt ID | Function/Structure |
CSP | Cysteine String Protein, DnaJC5 | 80331 | Q9H3Z4 | Secretory vesicle protein involved in regulated exocytosis; plays a role in CFTR biogenesis and trafficking; interacts with the inactive GDP- bound form of Galpha(s) and promotes GDP/GTP exchange; guanine nucleotide exchange activity regulated by Hsc70 and SGT |
CSP-beta | DnaJC5B | 85479 | Q9UF47 | Testis specific expression; palmitoylated |
CSP-gamma | DnaJC5G | 285126 | Q8N7S2 | Testis specific expression; palmitoylated |
DnaJA4 | NA | 55466 | Q8WW22 | Hsp40 homolog |
DnaJA5 | NA | 134218 | Q5F1R6 | Hsp40 homolog; three splice variants; expressed in brain, placenta, kidney, and pancreas |
DnaJB12 | NA | 54788 | Q9NXW2 | Possibly membrane-associated |
DnaJB13 | TSARG6 | 374407 | P59910 | Expressed specifically in adult testis, implicated in apoptosis in spermatogenic cells |
DnaJB14 | NA | 79982 | Q8TBM8 | Possibly membrane-associated; two splice variants |
DnaJB8 | NA | 165721 | Q8NHS0 | Hsp40 homolog |
DnaJC11 | FLJ10737 | 55735 | Q9NVH1 | Candidate tumor suppressor gene of neuroblastoma; found in mitochondria |
DnaJC16 | NA | 23341 | Q9Y2G8 | Possibly type IV single-pass membrane protein; two splice variant |
DnaJC17 | NA | 55192 | Q9NVM6 | Hsp40 homolog; contains RNA recognition motif |
DnaJC18 | NA | 202052 | Q9H819 | Possibly single-pass membrane protein |
DnaJC19 | TIM14 | 131118 | Q96DA6 | Mitochondrial protein, similar in sequence to yeast Tim14 which is involved in mitochondrial protein import; mutated in DCMA syndrome (dilated cardiomyopathy with ataxia) |
DnaJC4 | HSPF2; MCG18 | 3338 | Q9NNZ3 | Possibly single-pass membrane protein |
DnaJC6 | DJC6 | 9829 | O75061 | Involved in uncoating of clathrin coated vesicles; interacts with Hsc70; three splice variants |
DnaJC7 | TPR2; TTC2 | 7266 | Q99615 | Interacts with GAP domain of NF1 |
DnaJC8 | SPF31 | 22826 | O75937 | Splicing protein spf31 |
DRIP78 | HDJ3; DnaJC14 | 85406 | Q6Y2X3 | May regulate trafficking of GPCR's including Angiotensin II and Dopamine Receptor; may play a role as a chaperone in the assembly of G-beta/gamma subunits |
ERdj3 | DnaJB11, ERj3, HEDJ; ABBP-2 | 51726 | Q9UBS4 | ER localized, expression induced by ER stress; stimulates BiP ATPase activity |
ERdj5 | JPDI; DnaJC10 | 54431 | Q8IXB1 | ER localized, expression induced by ER stress (UPR); also a member of the Protein Disulfide Isomerase family |
Hdj2 | DnaJA1, DJ2; DJA1; HSDJ; HSJ2 | 3301 | P31689 | Farnesylated; interacts with Hsc70; two splice forms, one nuclear, one expressed throughout the cell |
HdjC9 | JDD1; DnaJC9 | 23234 | Q8WXX5 | Hsp40 homolog |
Hlj1 | DnaJB4, DjB4; DnaJW | 11080 | Q9UDY4 | Identified in human liver |
HSC3 | DnaJB7 | 150353 | Q7Z6W7 | ER localized, expression induced by ER stress (UPR); also a member of the Protein Disulfide Isomerase family |
Hsc40 | DnaJB5 | 25822 | O75953 | Constitutive Hsp40 isoform |
HscB | DnaJC20, Jac1, Hsc20 | 150274 | Q8IWL3 | Homolog of E. coli HscB, which along with the E. coli Hsp70 homolog HscA forms part of a specialized system for synthesizing iron-sulfur proteins; candidate gene in hereditary ataxia syndromes |
Hsj1 | DnaJB2, HSPF3 | 3300 | P25686 | Neuronal tissue-specific; two isoforms (Hsj1a and Hsj1b) |
Hsp40/Hdj1 | DnaJB1, HSPF1 | 3337 | P25685 | Enhances ATPase activity of Hsp70 family members |
Htj1/ERdj1 | DNAJC1, DNAJL1, MTJ1 | 64215 | Q96KC8 | Enriched in microsomes and nucleus; stimulates BiP ATPase activity; involved in transport of BiP to the cell surface |
JDP1 | DnaJC12 | 56521 | Q9UKB3 | An estrogen target gene, highly expressed in ER positive breast cancer; two isoforms; conserved down to Drosophila |
MCJ | HSD18, DNAJD1, DNAJC15 | 29103 | Q9Y5T4 | Methylation controlled J protein (MCJ) is a type II transmembrane cochaperone localized in the Golgi network and present only in vertebrates |
Mdg1/ERdj4 | DnaJB9 | 4189 | Q9UBS3 | ER localized, expression induced by UPR; expression associated with low metastatic potential; stimulates BiP ATPase activity |
MPP11 | MIDA1, DnaJC2, Zrf1, Zrf2 | 22791 | P54103 | Localized to nucleus; ubiquitously expressed |
Mrj | DnaJB6, Hsj2; Msj1 | 10049 | O75190 | Enriched in the CNS; two isoforms as a result of alternative splicing; one nuclear, one expressed throughout the cell; binds and regulates NFAT |
P58(IPK) | DnaJC3, PRKRI; | 5611 | Q13217 | Binds and inactivates PKR; induced by ER stress, binds and inactivates PERK |
Rdj2 | DnaJA2, DJA2 | 10294 | O60884 | Hsc70 co-chaperone; possibly membrane-associated and farnesylated |
RME-8 | DnaJC13 | 23317 | O75165 | Functions in endosomal trafficking; human homolog of Receptor-mediated endocytosis 8 (RME8) in C. elegans; widely expressed, binds Hsc70 |
Tid1 | hTid-1, DnaJA3 | 9093 | Q96EY1 | Mitochondrial; modulates apoptotic signal transduction, cytochrome c release, and caspase 3 activation; two splice variants |