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14-3-3ε (human), (recombinant) (untagged)

ENZ-PRT209-0100 100 µg 1,083.00 USD
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Product Details

Sequence:~30 kDa
Source:Produced in E. coli.
UniProt ID:P62258
Formulation:Liquid. In 20 mM Tris-HCl, pH 8, containing 100 mM NaCl.
Purity:≥90% (SDS-PAGE)
Purity Detail:Purified by multi-step chromatography
Application Notes:Drug screening, protein-protein interaction studies, gel overlays.
Shipping:Dry Ice
Long Term Storage:-80°C
Handling:Avoid freeze/thaw cycles.
Scientific Background:14-3-3 proteins are dimeric phosphoserine/phosphothreonine binding proteins, which have been shown to be involved in the regulation of many crucial processes such as signal transduction, cell-cycle control, apoptosis, protein localization, phosphorylation state and stability, transcription, metabolism, and malignant transformation. 14-3-3ε is implicated in an early left-right patterning in amphibian embryos. In addition, children with Miller-Dieker syndrome, a severe brain malformation associated with mental retardation, have heterozygous deletions of both the 14-3-3ε and LIS1 genes. It has also been shown to be the only 14-3-3 isoform associated with prion protein amyloid deposits of Gerstmann-Straussler-Scheinker disease.
Regulatory Status:RUO - Research Use Only

Product Literature References

Activation of innate immunity by 14-3-3 ϵ, a new potential alarmin in osteoarthritis: M. Millerand, et al.; Osteoarthritis Cartilage 28, 646 (2020), Abstract;

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