| ENZ-ABS293-0100 | 100 µg | 471.00 USD |  |
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| Alternative Name: | MAP3K1, MEK kinase 1, Mitogen-activated protein kinase kinase kinase 1, MAPK/ERK kinase kinase 1, MAPKKK1 |
| Host: | Rabbit |
| Immunogen: | Recombinant MEKK1 (aa 1307-1509). |
| UniProt ID: | Q13233 |
| Species reactivity: | Human |
| Applications: | ELISA, ICC, IHC (FS), IHC (PS), WB |
| Recommended Dilutions/Conditions: | ELISA (1:100-200) Immunocytochemistry (formalin fixed cells) (1:100-500) Immunohistochemistry (frozen sections) (1:100-500) Immunohistochemistry (paraffin sections) (1:50-200) Western blot (1:100-400) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~26KDa by Western blot. |
| Positive Control: | Included. |
| Purity Detail: | Affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | MEKKs (Mitogen activated protein kinase kinase kinases) are serine-threonine kinases that act as the first tier of cellular MAP kinase pathways by activation of MAP/ERK kinases, or MEKs. Many enzymes with MEKK activity have been identified, including MEKK1-4, Raf, MLK3, TAK, and DLK. MEKKs generally display little similarity outside of their catalytic kinase domains. MEKK1-4 are nearly 50% identical within their catalytic domains, and are known to regulate Erk, Jnk, and p38 MAP kinase pathways. MEKK2 and MEKK3 bind MEK5 via conserved PB1 domains, leading to downstream activation of Erk5. |
| Regulatory Status: | RUO - Research Use Only |
Goat anti-rabbit IgG, polyclonal antibody (HRP conjugate) |
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| ELISA, IHC, WB | Print as PDF | ||||||
| ADI-SAB-300-J | 1 ml | 154.00 USD | |
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