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Prostaglandin H2/thromboxane A2 receptor agonist
BML-PG023-0001 1 mg 174.00 USD
BML-PG023-0010 10 mg 1,101.00 USD
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Replaces Prod. #: ALX-340-015

  • Potent TP agonist
  • Used in cardiovascular studies
  • highly cited
U-46619 is a Prostaglandin H2/thromboxane A2 analog and a potent thromboxane A2 receptor (TP) agonist (EC50 = 0.035µM). U-46619 induces platelet shape change and aggregation at 32nM. U-46619 also activates p38 MAPK.

Product Details

Alternative Name:9,11-Dideoxy-9α,11α-methanoepoxy prostaglandin F, 9,11-Dideoxy-9α,11α-methanoepoxy prosta5Z,13E-dien-1-oic acid
Purity:≥98% (TLC)
Identity:Identity determined by 1H-NMR.
Appearance:Pale yellow oil.
Solubility:Soluble in DMF (100mg/ml), DMSO, 100% ethanol, DMSO, or PBS, pH 7.2 (2mg/ml).
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 years after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Technical Info/Product Notes:Note: Product is not sterile.
Regulatory Status:RUO - Research Use Only
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Product Literature References

MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma: L.S. Danielson, et al.; PLoS One 18, e0278844. (2023), Abstract;
Inhibition of neurogenic contractions in renal arteries and of cholinergic contractions in coronary arteries by the presumed inhibitor of ADP-ribosylation factor 6, NAV2729: R. Huang, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 395, 471 (2022), Abstract;
Long-term administration of resveratrol and MitoQ stimulates cavernosum antioxidant gene expression in a mouse castration model of erectile dysfunction: C.J. Pierre, et al.; Life Sci. 310, 121082 (2022), Abstract;
Permixon®, hexane-extracted Serenoa repens, inhibits human prostate and bladder smooth muscle contraction and exerts growth-related functions in human prostate stromal cells: A. Tamalunas, et al.; Life Sci. 308, 120931 (2022), Abstract;
Bleeding diathesis in mice lacking JAK2 in platelets: N. Eaton, et al.; Blood Adv. 5, 2969 (2021), Abstract;
Correlation of Pulse Wave Transit Time with Pulmonary Artery Pressure in a Porcine Model of Pulmonary Hypertension: F. Mueller-Graf, et al.; Biomedicines 9, 1212 (2021), Abstract;
Genetic Labeling of Cells Allows Identification and Tracking of Transgenic Platelets in Mice: I. Krüger, et al.; Int. J. Mol. Sci. 22, 3710 (2021), Abstract; Full Text
Lenalidomide and pomalidomide inhibit growth of prostate stromal cells and human prostate smooth muscle contraction: A. Tamalunas, et al.; Life Sci. 281, 119771 (2021), Abstract;
Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion: S. Stahnke, et al.; Curr. Biol. 31, 2051 (2021), Application(s): In vitro stimulation of platelets, Abstract;
Pharmacology of the single isomer, esuberaprost (beraprost-314d) on pulmonary vascular tone, IP receptors and human smooth muscle proliferation in pulmonary hypertension: L. Shen, et al.; Biochem. Pharmacol. 166, 242 (2019), Abstract;
Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism: M. Absi, et al.; PLoS One 14, e0220473 (2019), Abstract; Full Text
Vitamin C Deficiency Reduces Muscarinic Receptor Coronary Artery Vasoconstriction and Plasma Tetrahydrobiopterin Concentration in Guinea Pigs: G.F. Skovsted, et al.; Nutrients 9, 691 (2017), Application(s): Guinea Pig samples, Abstract; Full Text
Broad-range TRP channel inhibitors (2-APB, flufenamic acid, SKF-96365) affect differently contraction of resistance and conduit femoral arteries of rAT: M. Bencze, et al.; Eur. J. Pharmacol. 765, 533 (2015), Application(s): Induced arterial contractions, Abstract;
Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the pre-contractile agents: C. Benyahia, et al.; Prostaglandins Other Lipid Mediat. 121, 46 (2015), Application(s): Evaluating the effects of PGI2 mimetics in rat pulmonary arteries, Abstract;
Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation: N.S. Kirkby, et al.; FASEB. J. 29, 4568 (2015), Abstract; Full Text
αB-crystallin reduces ristocetin‑induced soluble CD40 ligand release in human platelets: Suppression of thromboxane A2 generation: M. Tsujimoto, et al.; Mol. Med. Rep. 12, 357 (2015), Application(s): Platelet aggregation in human platelet-rich plasma, Abstract;
Liposomal nanoparticles encapsulating iloprost exhibit enhanced vasodilation in pulmonary arteries: P.P. Jain, et al.; Int. J. Nanomedicine 9, 3249 (2014), Abstract; Full Text
EV-077 in vitro inhibits platelet aggregation in type-2 diabetics on aspirin: K.S. Sakariassen, et al.; Thromb. Res. 130, 746 (2012), Abstract;
Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis: S. Pfister, et al.; J. Thorac. Cardiovasc. Surg. 141, 425 (2011), Abstract; Full Text
Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways: C. Pan, et al.; Ther. Adv. Cardiovasc. Dis. 5, 99 (2011), Abstract;
Secretoneurin facilitates endothelium-dependent relaxations in porcine coronary arteries: C.K. Chan, et al.; Am. J. Physiol. Heart Circ. Physiol. 300, H1159 (2011), Abstract; Full Text
Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice: K. Yamashiro, et al.; J. Cereb. Blood. Flow Metab. 30, 1494 (2010), Abstract; Full Text
Calcium-independent phospholipase A(2) plays a key role in the endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.: M.S. Wong, et al.; Am. J. Physiol. Heart Circ. Physiol. 298, H1260 (2010), Abstract; Full Text
Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue: J. Saklatvala, et al.; J. Biol. Chem. 271, 6586 (1996), Abstract; Full Text
Heterogeneity of thromboxane A2 (TP-) receptors: evidence from antagonist but not agonist potency measurements: P.M. Tymkewycz, et al.; Br. J. Pharmacol. 102, 607 (1991), Abstract;
Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets: N. Liel, et al.; Prostaglandins 33, 789 (1987), Abstract;
Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues: S.E. Burke, et al.; Br. J. Pharmacol. 78, 287 (1983), Abstract;
Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations: R.A. Coleman, et al.; Br. J. Pharmacol. 73, 773 (1981), Abstract;

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