Replaces Prod. #: ALX-350-014
Potent cell permeable inhibitor with high specificity for protein phosphatase 1 (PP1) and 2A (PP2A). Inhibits p130cas tyrosine phosphorylation. Enhances the phosphorylation level of NF-κB. Affects intracellular signalling processes that require 14-3-3. Potent non-phorbol type tumor promoter. Prevents γ-radiation induced apoptosis. Stimulates contraction of smooth muscle, induces intracellular protein phosphorylation in cultured human keratinocytes. Inhibits apoptosis. No effect on acid or alkaline phosphatases at 1µM. Treatment of MCF7 cells (breast cancer line), with 100nM, produced rapid (<20 min.) but incomplete inhibition of both PP1 (~60%) and PP2A (~70%).
Product Details
Formula: | C50H81N4O15P |
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MW: | 1009.2 |
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CAS: | 101932-71-2 |
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Purity: | ≥98% (HPLC) |
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Appearance: | Clear film or white crystalline powder. |
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Solubility: | Soluble in DMSO, 100% ethanol and dimethyl formamide. |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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