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MPTP inhibitor
BML-CM115-0010 10 mg 81.00 USD
BML-CM115-0050 50 mg 304.00 USD
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Replaces Prod. #: ALX-270-293

  • MPTP inhibitor used in cellular metabolism studies
Decylubiquinone is an analogue of ubiquinone. Decylubiquinone inhibits the Ca2+-dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration. Maximum effect on Ca2+ retention capacity of rat liver mitochondria can be achieved with decylubiquinone at 100μM. This inhibitory effect of decylubiquinone on MPTP can be counteracted by ubiquinone-5 (Prod. No. ALX-270-294). Decylubiquinone also inhibits etoposide-induced apoptosis in in L929 cells at 5μM.

Product Details

Alternative Name:2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
Purity:≥97% (HPLC)
Appearance:Neat yellow to orange colored oil.
Solubility:Soluble in DMSO (10mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
BML-CM115 structure
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BML-CM115 structure

Product Literature References

Stimulation of cholesterol biosynthesis in mitochondrial complex I-deficiency lowers reductive stress and improves motor function and survival in mice: T.J. Schirris, et al.; Biochim. Biophys. Acta Mol. Basis Dis. 1867, 166062 (2021), Abstract;
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism: M.G. Acoba, et al.; Cell Rep. 34, 108869 (2021), Abstract; Full Text
Disruption of acetyl-lysine turnover in muscle mitochondria promotes insulin resistance and redox stress without overt respiratory dysfunction: A. Williams, et al.; Cell Metab. 31, 131 (2019), Abstract; Full Text
X-Ray Structure of Human Sulfide:Quinone Oxidoreductase: Insights into the Mechanism of Mitochondrial Hydrogen Sulfide Oxidation: M. Jackson, et al.; Structure 27, 794 (2019), Abstract; Full Text
The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c: N.O. Karpinich, et al.; J. Biol. Chem. 277, 16547 (2002), Abstract; Full Text
A ubiquinone-binding site regulates the mitochondrial permeability transition pore: E. Fontaine, et al.; J. Biol. Chem. 273, 25734 (1998), Abstract; Full Text

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