Bongkrekic acid is an inhibitory ligand of the mitochondrial adenine nucleotide translocase. It inhibits mitochondrial permeability transition pore opening. At 50 µM it inhibits dexamethasone- apoptosis in thymocytes, preventing the PARP cleavage and DEVDase (caspase-3 like) activity normally produced by these treatments.
Product Details
| Formula: | C28H38O7 . 3 NH3 |
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| MW: | 537.7 |
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| CAS: | 1177154-51-6 |
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| Purity: | ≥92% (HPLC) |
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| Appearance: | Beige to pink lyophilized solid. |
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| Reconstitution: | Reconstitute to 1mg/ml with distilled water |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders: E.G. Lin-Hendel, et al.; Cell Rep.
15, 229 (2016),
Abstract;
Full Text
The adenine nucleotide translocase modulates oligomycin-induced quenching of pyranine fluorescence in submitochondrial particles: M. Ziegler et al.; J. Biol. Chem.
268, 25320 (1993),
Abstract;
