Replaces Prod. #: ALX-430-136
Necrostatin-1 inhibits necroptosis, a non-apoptotic cell death pathway. Inhibits the loss of mitochondrial membrane potential in TNFα-treated Jurkat cells (EC50=490 nM). Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. It displays a pronounced protective effect in a mouse model of ischemic brain injury and inhibits myocardial cell death. Inhibits RIP1 kinase the key upstream kinase involved in the activation of necroptosis (EC50=180nM).
Product Details
| Alternative Name: | Methylthiohydantoin-DL-tryptophan |
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| Formula: | C13H13N3OS |
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| MW: | 259.3 |
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| CAS: | 4311-88-0 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (20mg/ml) or 100% ethanol (5mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent: C. Lagler, et al.; PLoS One
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Caspase-3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice: M.O. Grootaert, et al.; Oxid. Med. Cell Longev.
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Simultaneous induction of apoptosis and necroptosis by Tanshinone IIA in human hepatocellular carcinoma HepG2 cells: C.Y. Lin, et al.; Cell Death Discov.
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ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly: T. Selmi, et al.; BMC Cancer
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A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis: G. Kung, et al.; Cell Death Differ.
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Betulinic acid-induced mitochrondria-dependent cell death is counter balanced by an autophagic salvage: L. Potze, et al.; Cell Death Dis.
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TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis: I. Karl, et al.; Cell Death Dis.
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The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB: A. Fontanini et al.; J. Biol. Chem.
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Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells: X. Xu et al.; J. Neurochem.
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