Necroptosis inhibitor. In contrary to the mechanism of necrostatin-1 (Prod.No. BML-AP309) it was shown that necrostatin-5 inhibits RIP1 kinase indirectly. A potent inhibitor of immunoprecipitated, but not recombinant RIP1.
Product Details
| Alternative Name: | Nec-5, 3-p-Methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide |
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| Formula: | C19H17N3O2S2 |
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| MW: | 383.5 |
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| CAS: | 337349-54-9 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (>10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Scientific Background: | The necrostatins inhibit non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. There are three different mechanisms: T-loop dependent inhibition by necrostatin-1, partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Retinal pigment epithelial cell necroptosis in response to sodium iodate: J. Hanus, et al.; Cell Death Discov.
2, 16054 (2016),
Application(s): Cell culture, transfection, treatments, and MTT assay (human cells),
Abstract;
Full Text
Idenfication of RIP1 kinase as a specific cellular target of necrostatins: A. Degterev, et al.; Nat. Chem. Biol.
4, 313 (2008),
Abstract;
Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5 : K. Wang, et al.; Bioorg. Med. Chem. Lett.
17, 1455 (2007),
Abstract;
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