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Necrox-5™ . methanesulfonate

Necrosis inhibitor
ALX-430-167-M001 1 mg 151.00 USD
ALX-430-167-M005 5 mg 463.00 USD
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Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1μM NecroX™-5 prevented ~50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.

Product Details

Alternative Name:[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine
Formula:C25H31N3O3S . 2 CH4O3S
Purity:≥95% (HPLC)
Appearance:Off-white to light pink solid.
Solubility:Soluble in DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light and keep under inert gas.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Necrocide 1 Mediates a Non-Apoptotic Necrotic Cell Death and Immunogenic Response in Human Cancer Cells: J. Zhang, et al.; Cell Death Dis. 14, 238 (2023), Abstract;
Down-regulation of intracellular reactive oxygen species attenuates P-glycoprotein-associated chemoresistance in Epstein-Barr virus-positive NK/T-cell lymphoma: Y.S. Nam, et al.; Am. J. Transl. Res. 11, 1359 (2019), Abstract;
Necrotic cell death in atherosclerosis: W. Martinet, et al.; Basic Res. Cardiol. 106, 749 (2011), Abstract;
NecroX as a novel class of mitochondrial reactive oxygen species and ONOO(-) scavenger: H.J. Kim, et al.; Arch. Pharm. Res. 33, 1813 (2010), Abstract;

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