Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1µM NecroX™-2 prevented ~50% cell death in H9C2 cells exposed to 400µM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro.
Product Details
| Alternative Name: | [5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine |
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| Formula: | C25H32N4O4S2 |
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| MW: | 516.7 |
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| Purity: | ≥95% (NMR, LCMS) |
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| Appearance: | Gray powder. |
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| Solubility: | Soluble in DMSO (>10mg/ml). |
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| Application Notes: | For in vitro applications, dissolve in DMSO to 20-50mM stock solution and dilute further in cell culture media. Treat cells with 30µM to 0.1µM final concentration.
Optimal conditions must be determined individually for each application. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Necrocide 1 Mediates a Non-Apoptotic Necrotic Cell Death and Immunogenic Response in Human Cancer Cells: J. Zhang, et al.; Cell Death Dis.
14, 238 (2023),
Abstract;
The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity: Q. Li, et al.; Nat. Commun.
6, 6183 (2015),
Application(s): Cell Culture,
Abstract;
Necrotic cell death in atherosclerosis: W. Martinet, et al.; Basic Res. Cardiol.
106, 749 (2011),
Abstract;
NecroX as a novel class of mitochondrial reactive oxygen species and ONOO(-) scavenger: H.J. Kim, et al.; Arch. Pharm. Res.
33, 1813 (2010),
Abstract;
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